Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects

Luigina Guasti, Cinzia Simoni, Luca Mainardi, Chiara Crespi, Maria Grazia Cimpanelli, Catherine Klersy, Giovanni Gaudio, Romeo Codari, Lorenzo Maroni, Franca Marino, Marco Cosentino, Anna Maria Grandi, Sergio Cerutti, Achille Venco

Research output: Contribution to journalArticle

Abstract

A cardiovascular over-reactivity to stress may participate in the pathophysiology of hypertension. The aim of this study was to investigate whether baseline indexes of autonomic modulation of heart rate or baroreflex sensitivity were correlated with cardiovascular reactivity to stress. Spectral parameters of RR interval variability and the LFalpha-index were calculated in a resting condition in 53 untreated subjects (34 hypertensives; 19 normotensives). The reactivity to stress was expressed as changes of mean RR and systolic blood pressure during arithmetic mental stress testing. The cardiovascular reactivity was not correlated with either baseline spectral parameters of RR interval variability or LFalpha-index. In the multivariate analysis no confounding effect of diagnosis (hypertension vs normotension) was found. Moreover no interaction between diagnosis and both LF/HF ratio and LFalpha-index was observed. Thus, the cardiovascular response to a mental stimulus appears to prevail over the baseline pattern of cardiovascular regulation independently of the presence or absence of the hypertensive disease.

Original languageEnglish
Pages (from-to)258-263
Number of pages6
JournalInternational Journal of Psychophysiology
Volume71
Issue number3
DOIs
Publication statusPublished - Mar 2009

Keywords

  • Baroreflex gain
  • Cardiovascular reactivity
  • Heart rate variability
  • Hypertension-essential
  • Spectral analysis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)
  • Neuropsychology and Physiological Psychology

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    Guasti, L., Simoni, C., Mainardi, L., Crespi, C., Cimpanelli, M. G., Klersy, C., Gaudio, G., Codari, R., Maroni, L., Marino, F., Cosentino, M., Grandi, A. M., Cerutti, S., & Venco, A. (2009). Lack of relationship between cardiovascular reactivity to mental stress and autonomic modulation of the sinoatrial node in normotensive and hypertensive male subjects. International Journal of Psychophysiology, 71(3), 258-263. https://doi.org/10.1016/j.ijpsycho.2008.10.006