Lack of relationship between CO2 reactivity and serotonin transporter gene regulatory region polymorphism in panic disorder

Giampaolo Perna, Daniela Di Bella, Elisa Favaron, Michele Cucchi, Laura Liperi, Laura Bellodi

Research output: Contribution to journalArticle

Abstract

Changes in the function of the serotonergic system influence both panic phobic symptoms and carbon dioxide (CO2) reactivity in patients with panic disorder. Schmidt et al. [2000: J Abnorm Psychol 109(2):308-320] recently reported a predictive role of the genetic variants of the 5-HTTLPR on the fearful response to CO2 in healthy controls. We tested the hypothesis that the heterogeneity of CO2 reactivity in patients with panic disorder could be related to the allelic variation of the 5-HTT promoter. Ninety-five patients with panic disorder were challenged with 35% CO 2. 5-HTTLPR allelic variation in each subject was determined using a PCR-based method. There were no differences for all the measures of CO 2 reactivity among the genotype groups. CO2 reactivity of patients with panic disorder seems not to be influenced by the genetic variants of the 5-HTTLPR; this finding does not support a role for the serotonin transporter in the etiopathogenesis of CO2 reactivity in panic disorder.

Original languageEnglish
Pages (from-to)41-43
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume129 B
Issue number1
Publication statusPublished - Aug 15 2004

Keywords

  • 5-HTTLPR
  • Carbon dioxide
  • Panic disorder
  • Panic provocation
  • Polymorphism
  • Serotonin

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

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