Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus

Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Francisco J. Blanco, Ana Suarez, Maria J. Santos, Chryssa Papasteriades, Patricia Carreira, Rudolf Pullmann, Josep Ordi-Ros, Maurizio Marchini, Fotini N. Skopouli, Marc Bijl, Nadia Barrizone, Gian D. Sebastiani, Sergio Migliaresi, Torsten Witte, Bernard R. Lauwerys, Attila Kovacs, Sarka RuzickovaJuan J. Gomez-Reino, Antonio Gonzalez, Myriam Liz, Iris Kappou-Rigatou, Lorenzo Beretta, Eva Balada, Cees G. Kallenberg, Filipe Vinagre, Maria Mavromati, Carmen Gutierrez, Ignacio Rego, Sandra D'Alfonso, Reinhold E. Schmidt, Emöke Endreffy, Ctibor Dostal

Research output: Contribution to journalArticle

Abstract

Introduction: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE.Methods: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRSs).Results: Our results did not replicate those of the previous study at either the level of individual loci or the global level of GRSs. GRSs were larger in women than in men (4.20 ± 1.07 in women vs. 3.27 ± 0.98 in men). This very significant difference (P <10-16) was more dependent on the six new loci not included in the previous study (59% of the difference) than on the thirteen loci that are shared (the remaining 41%). However, the 13 shared loci also showed a higher genetic risk load in women than in men in our study (P = 6.6 × 10-7), suggesting that heterogeneity of participants, in addition to different loci, contributed to the opposite results.Conclusion: Our results show the lack of a clear trend toward higher genetic risk in one of the sexes for the analyzed SLE loci. They also highlight several limitations of assessments of genetic risk load, including the possibility of ascertainment bias with loci discovered in studies that have included mainly women.

Original languageEnglish
Article numberR128
JournalArthritis Research and Therapy
Volume16
Issue number3
DOIs
Publication statusPublished - Jun 19 2014

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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    Alonso-Perez, E., Suarez-Gestal, M., Calaza, M., Blanco, F. J., Suarez, A., Santos, M. J., Papasteriades, C., Carreira, P., Pullmann, R., Ordi-Ros, J., Marchini, M., Skopouli, F. N., Bijl, M., Barrizone, N., Sebastiani, G. D., Migliaresi, S., Witte, T., Lauwerys, B. R., Kovacs, A., ... Dostal, C. (2014). Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus. Arthritis Research and Therapy, 16(3), [R128]. https://doi.org/10.1186/ar4585