Mancato effetto della temporizzazione della chirurgia in relazione con il ciclo mestruale sulla prognosi del cancro della mammella nelle donne in premenopausa.

Translated title of the contribution: Lacking effect of timing of surgery in relation to the menstrual cycle on prognosis of breast cancer in premenopausal women

G. Mondini, D. Friedman, F. De Cian, C. Spirito, S. Carrabetta, M. Costantini, M. P. Sormani, D. Civalleri

Research output: Contribution to journalArticle

Abstract

The influence of timing of surgery in relation to menstrual period on survival of breast cancer patients has been both advanced advocated and disputed. A meta-analysis on published series showed a statistically significant overall odds reduction when surgery is performed in the luteal phase. The records of 165 premenopausal M- breast cancer women, not on hormonal therapies, consecutively operated on from 1977 to 1991 were reviewed. All patients underwent modified radical mastectomies or quadrantectomies plus operative radiotherapy, Node-positive patients received standard adjuvant chemotherapy. Cox regression analysis was used to estimate the relative risk (RR) of death in three models including timing of surgery, age, histology, pathological T and N. In each model, patients were divided into two groups according to the criteria proposed by Badwe, Hrushesky, and Senie. Multivariate analysis showed a significant association between pT and pN and survival, whereas no association with survival was observed for timing of surgery according to Badwe or Hrushesky or Senie criteria (RR = 1.26, RR = 0.91, and RR = 0.88 respectively). Up-to-date agreement on the menstrual phase and relative expected better prognosis is still lacking.

Translated title of the contributionLacking effect of timing of surgery in relation to the menstrual cycle on prognosis of breast cancer in premenopausal women
Original languageItalian
Pages (from-to)7-11
Number of pages5
JournalGiornale di Chirurgia
Volume18
Issue number1-2
Publication statusPublished - Jan 1997

ASJC Scopus subject areas

  • Surgery

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