TY - JOUR
T1 - Lacosamide as add-on in brain tumor-related epilepsy
T2 - Preliminary report on efficacy and tolerability
AU - Maschio, M.
AU - Dinapoli, L.
AU - Mingoia, M.
AU - Sperati, F.
AU - Pace, A.
AU - Pompili, A.
AU - Carapella, C. M.
AU - Vidiri, A.
AU - Muti, P.
PY - 2011/11
Y1 - 2011/11
N2 - Lacosamide (LCM) is an antiepileptic drug (AED) that has demonstrated a good efficacy in controlling seizures as an add-on in adult epilepsy. To date, there have been no studies on LCM in patients with brain tumor-related epilepsy (BTRE). To evaluate efficacy and tolerability of LCM as an add-on in BTRE, we followed 14 patients suffering from BTRE who had already been treated with other AEDs and who had not experienced adequate seizure control. Eleven patients underwent chemotherapy while being treated with LCM. Mean duration of follow up was 5.4 months (min <1 max 10 months). Mean seizure number in the last month prior to the introduction of LCM had been 15.4. At last follow-up, the mean seizure number was reduced to 1.9/month. Lacosamide mean dosage was of 332.1 mg/day (min 100 max 400 mg/day). Responder rate was 78.6%. One patient discontinued LCM because of side-effects. There were no other reported side-effects. Preliminary data on the use of LCM in add-on in patients with BTRE indicate that this drug may represent a valid alternative as an add-on in this particular patient population. However, larger samples are necessary in order to draw definitive conclusions.
AB - Lacosamide (LCM) is an antiepileptic drug (AED) that has demonstrated a good efficacy in controlling seizures as an add-on in adult epilepsy. To date, there have been no studies on LCM in patients with brain tumor-related epilepsy (BTRE). To evaluate efficacy and tolerability of LCM as an add-on in BTRE, we followed 14 patients suffering from BTRE who had already been treated with other AEDs and who had not experienced adequate seizure control. Eleven patients underwent chemotherapy while being treated with LCM. Mean duration of follow up was 5.4 months (min <1 max 10 months). Mean seizure number in the last month prior to the introduction of LCM had been 15.4. At last follow-up, the mean seizure number was reduced to 1.9/month. Lacosamide mean dosage was of 332.1 mg/day (min 100 max 400 mg/day). Responder rate was 78.6%. One patient discontinued LCM because of side-effects. There were no other reported side-effects. Preliminary data on the use of LCM in add-on in patients with BTRE indicate that this drug may represent a valid alternative as an add-on in this particular patient population. However, larger samples are necessary in order to draw definitive conclusions.
KW - Antiepileptic drugs
KW - Brain tumor-related epilepsy
KW - Lacosamide
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U2 - 10.1007/s00415-011-6132-8
DO - 10.1007/s00415-011-6132-8
M3 - Article
C2 - 21674196
AN - SCOPUS:84857660393
VL - 258
SP - 2100
EP - 2104
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 11
ER -