Lacosamide on background eeg activity in brain tumor-related epilepsy patients: A case series study

Marta Maschio, Alessia Zarabla, Andrea Maialetti, Francesca Sperati, Loredana Dinapoli, Sabrina Dispenza, Gianluca Petreri, Tonino Cantelmi

Research output: Contribution to journalComment/debate

Abstract

Objective: Therapeutic doses of antiepileptic drugs (AEDs) may alter EEG background activity, which is considered an index of the functional state of the brain. Quantitative analysis (qEEG) of EEG background activity is a valid instrument to assess the effects of many centrally active drugs on the central nervous system, including AEDs. Lacosamide (LCM) is a new AED that could be a valid therapeutic choice in patients with brain tumor-related epilepsy (BTRE). Methods: We used qEEG to analyze the possible effect of LCM as an add-on, on background EEG activity after 4 months in patients with BTRE. Results: We consecutively recruited sixteen patients with BTRE: Five dropped out for disease progression, five for scarce compliance, and six completed the study. For these reasons qEEG was performed at first visit and after 4 months only in six patients. For all frequency bands, LCM revealed no changes of mean relative power during rest with eyes closed, hyperpnoea (HP), and mental arithmetic task (MA); significant increment was found only in the theta mean relative power during opening and closing eyes (BR). After four months of therapy with LCM, one patient was seizure free, four had a seizure reduction ≥50%, and one showed a worsening in seizure frequency <50%. Conclusion: Despite the limitation of a small series, these findings suggest that LCM seems to have only a mild interference on EEG background activity and confirm that LCM has a good efficacy on seizure control in patients with BTRE. This is the first study that evaluates the effect of LCM on background EEG activity, using qEEG in BTRE patients. Future research in this area could include prospective studies with qEEG for a longer follow-up period to assess the impact of AEDs on brain functions in this particular fragile patient population.

Original languageEnglish
Article numbere01067
JournalBrain and Behavior
Volume8
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

Fingerprint

Brain Neoplasms
Epilepsy
Electroencephalography
Anticonvulsants
Seizures
Central Nervous System Agents
lacosamide
Brain
Compliance
Disease Progression
Therapeutics
Prospective Studies
Population

Keywords

  • antiepileptic drugs
  • brain tumor-related epilepsy
  • EEG background activity
  • efficacy
  • lacosamide
  • quantitative EEG

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Lacosamide on background eeg activity in brain tumor-related epilepsy patients : A case series study. / Maschio, Marta; Zarabla, Alessia; Maialetti, Andrea; Sperati, Francesca; Dinapoli, Loredana; Dispenza, Sabrina; Petreri, Gianluca; Cantelmi, Tonino.

In: Brain and Behavior, Vol. 8, No. 11, e01067, 01.11.2018.

Research output: Contribution to journalComment/debate

Maschio, M, Zarabla, A, Maialetti, A, Sperati, F, Dinapoli, L, Dispenza, S, Petreri, G & Cantelmi, T 2018, 'Lacosamide on background eeg activity in brain tumor-related epilepsy patients: A case series study', Brain and Behavior, vol. 8, no. 11, e01067. https://doi.org/10.1002/brb3.1067
Maschio, Marta ; Zarabla, Alessia ; Maialetti, Andrea ; Sperati, Francesca ; Dinapoli, Loredana ; Dispenza, Sabrina ; Petreri, Gianluca ; Cantelmi, Tonino. / Lacosamide on background eeg activity in brain tumor-related epilepsy patients : A case series study. In: Brain and Behavior. 2018 ; Vol. 8, No. 11.
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AU - Maschio, Marta

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AU - Sperati, Francesca

AU - Dinapoli, Loredana

AU - Dispenza, Sabrina

AU - Petreri, Gianluca

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