Abstract
In infants with necrotizing enterocolitis (NEC), intestinal gangrene defines advanced disease. Since intestinal ischemia is considered a pathogenetic factor for intestinal gangrene, serum activity of mucosal and seromuscular enzymes may be elevated in these patients. Our aim was to evaluate if serum enzymes activity is increased in infants with NEC associated with intestinal gangrene. We performed a retrospective review of the case notes of infants operated on for NEC between 1998 and 2006. Patients with preoperative determination of serum enzymes were included in the study, and were divided into Group A and Group B based on the presence or absence of intestinal gangrene, respectively. Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in the two Groups. Values are medians (interquartile range). Thirty-five infants were operated on for NEC in the study period. Eighteen patients fulfilled the inclusion criteria: 12 in Group A and six in Group B. Group A patients had significantly higher LDH activity [1131.0 (1092.0-1300.0) vs. 482.0 (440.0-624.5) IU/L; P <0.005]. Our findings suggest that LDH activity may be increased in infants with NEC and intestinal gangrene. Its evaluation could be a further tool in the surgical decision making process in infants with NEC.
| Original language | English |
|---|---|
| Pages (from-to) | 705-709 |
| Number of pages | 5 |
| Journal | Pediatric Surgery International |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2008 |
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Keywords
- Intestinal gangrene
- Lactate dehydrogenase
- Necrotizing enterocolitis
- Neonate
- Serum enzymes activity
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis. / Morini, Francesco; Di Crosta, Ida; Ronchetti, Maria P.; Dituri, Francesco; Nahom, Antonella; Corchia, Carlo; Bagolan, Pietro.
In: Pediatric Surgery International, Vol. 24, No. 6, 06.2008, p. 705-709.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis
AU - Morini, Francesco
AU - Di Crosta, Ida
AU - Ronchetti, Maria P.
AU - Dituri, Francesco
AU - Nahom, Antonella
AU - Corchia, Carlo
AU - Bagolan, Pietro
PY - 2008/6
Y1 - 2008/6
N2 - In infants with necrotizing enterocolitis (NEC), intestinal gangrene defines advanced disease. Since intestinal ischemia is considered a pathogenetic factor for intestinal gangrene, serum activity of mucosal and seromuscular enzymes may be elevated in these patients. Our aim was to evaluate if serum enzymes activity is increased in infants with NEC associated with intestinal gangrene. We performed a retrospective review of the case notes of infants operated on for NEC between 1998 and 2006. Patients with preoperative determination of serum enzymes were included in the study, and were divided into Group A and Group B based on the presence or absence of intestinal gangrene, respectively. Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in the two Groups. Values are medians (interquartile range). Thirty-five infants were operated on for NEC in the study period. Eighteen patients fulfilled the inclusion criteria: 12 in Group A and six in Group B. Group A patients had significantly higher LDH activity [1131.0 (1092.0-1300.0) vs. 482.0 (440.0-624.5) IU/L; P <0.005]. Our findings suggest that LDH activity may be increased in infants with NEC and intestinal gangrene. Its evaluation could be a further tool in the surgical decision making process in infants with NEC.
AB - In infants with necrotizing enterocolitis (NEC), intestinal gangrene defines advanced disease. Since intestinal ischemia is considered a pathogenetic factor for intestinal gangrene, serum activity of mucosal and seromuscular enzymes may be elevated in these patients. Our aim was to evaluate if serum enzymes activity is increased in infants with NEC associated with intestinal gangrene. We performed a retrospective review of the case notes of infants operated on for NEC between 1998 and 2006. Patients with preoperative determination of serum enzymes were included in the study, and were divided into Group A and Group B based on the presence or absence of intestinal gangrene, respectively. Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in the two Groups. Values are medians (interquartile range). Thirty-five infants were operated on for NEC in the study period. Eighteen patients fulfilled the inclusion criteria: 12 in Group A and six in Group B. Group A patients had significantly higher LDH activity [1131.0 (1092.0-1300.0) vs. 482.0 (440.0-624.5) IU/L; P <0.005]. Our findings suggest that LDH activity may be increased in infants with NEC and intestinal gangrene. Its evaluation could be a further tool in the surgical decision making process in infants with NEC.
KW - Intestinal gangrene
KW - Lactate dehydrogenase
KW - Necrotizing enterocolitis
KW - Neonate
KW - Serum enzymes activity
UR - http://www.scopus.com/inward/record.url?scp=43749106224&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=43749106224&partnerID=8YFLogxK
U2 - 10.1007/s00383-008-2156-2
DO - 10.1007/s00383-008-2156-2
M3 - Article
C2 - 18414875
AN - SCOPUS:43749106224
VL - 24
SP - 705
EP - 709
JO - Pediatric Surgery International
JF - Pediatric Surgery International
SN - 0179-0358
IS - 6
ER -