Lactate dehydrogenase activity is increased in plasma of infants with advanced necrotizing enterocolitis

Francesco Morini, Ida Di Crosta, Maria P. Ronchetti, Francesco Dituri, Antonella Nahom, Carlo Corchia, Pietro Bagolan

Research output: Contribution to journalArticlepeer-review


In infants with necrotizing enterocolitis (NEC), intestinal gangrene defines advanced disease. Since intestinal ischemia is considered a pathogenetic factor for intestinal gangrene, serum activity of mucosal and seromuscular enzymes may be elevated in these patients. Our aim was to evaluate if serum enzymes activity is increased in infants with NEC associated with intestinal gangrene. We performed a retrospective review of the case notes of infants operated on for NEC between 1998 and 2006. Patients with preoperative determination of serum enzymes were included in the study, and were divided into Group A and Group B based on the presence or absence of intestinal gangrene, respectively. Serum activities of alkaline phosphatase (ALP), glutamic oxaloacetic transaminase (GOT), creatine kinase (CK), and lactate dehydrogenase (LDH) were compared in the two Groups. Values are medians (interquartile range). Thirty-five infants were operated on for NEC in the study period. Eighteen patients fulfilled the inclusion criteria: 12 in Group A and six in Group B. Group A patients had significantly higher LDH activity [1131.0 (1092.0-1300.0) vs. 482.0 (440.0-624.5) IU/L; P <0.005]. Our findings suggest that LDH activity may be increased in infants with NEC and intestinal gangrene. Its evaluation could be a further tool in the surgical decision making process in infants with NEC.

Original languageEnglish
Pages (from-to)705-709
Number of pages5
JournalPediatric Surgery International
Issue number6
Publication statusPublished - Jun 2008


  • Intestinal gangrene
  • Lactate dehydrogenase
  • Necrotizing enterocolitis
  • Neonate
  • Serum enzymes activity

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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