Lactate detection in the brain of growth-restricted fetuses with magnetic resonance spectroscopy

Irene Cetin, Barbara Barberis, Valentina Brusati, Erika Brighina, Luca Mandia, Andrea Arighi, Tatjana Radaelli, Pietro Biondetti, Nereo Bresolin, Giorgio Pardi, Mario Rango

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: The objective of the study was to determine the feasibility of detecting fetal brain lactate, a marker of fetal metabolic acidemia, using a noninvasive technique, proton magnetic resonance spectroscopy ( 1H MRS), in intrauterine growth-restricted (IUGR) fetuses. STUDY DESIGN: In vivo human fetal brain lactate detection was determined by 1H MRS in 5 fetuses with IUGR. Oxygenation and acid-base balance data were obtained at birth. RESULTS: 1H MRS analysis showed the presence of a lactate peak in the brain of the most severely affected IUGR fetus, with abnormal umbilical artery Doppler and fetal heart rate tracing. This finding was consistent with the low oxygen content and high lactic acid concentration observed in umbilical blood obtained at delivery. CONCLUSION: 1H MRS allows the noninvasive detection of cerebral lactate in IUGR fetuses. Lactate detected by 1H MRS may represent a possible marker of in utero cerebral injury or underperfusion.

Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number4
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Brain sparing
  • Fetal brain metabolism
  • Fetal distress
  • Placental insufficiency
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

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