TY - JOUR
T1 - Lactate detection in the brain of growth-restricted fetuses with magnetic resonance spectroscopy
AU - Cetin, Irene
AU - Barberis, Barbara
AU - Brusati, Valentina
AU - Brighina, Erika
AU - Mandia, Luca
AU - Arighi, Andrea
AU - Radaelli, Tatjana
AU - Biondetti, Pietro
AU - Bresolin, Nereo
AU - Pardi, Giorgio
AU - Rango, Mario
PY - 2011/10
Y1 - 2011/10
N2 - OBJECTIVE: The objective of the study was to determine the feasibility of detecting fetal brain lactate, a marker of fetal metabolic acidemia, using a noninvasive technique, proton magnetic resonance spectroscopy ( 1H MRS), in intrauterine growth-restricted (IUGR) fetuses. STUDY DESIGN: In vivo human fetal brain lactate detection was determined by 1H MRS in 5 fetuses with IUGR. Oxygenation and acid-base balance data were obtained at birth. RESULTS: 1H MRS analysis showed the presence of a lactate peak in the brain of the most severely affected IUGR fetus, with abnormal umbilical artery Doppler and fetal heart rate tracing. This finding was consistent with the low oxygen content and high lactic acid concentration observed in umbilical blood obtained at delivery. CONCLUSION: 1H MRS allows the noninvasive detection of cerebral lactate in IUGR fetuses. Lactate detected by 1H MRS may represent a possible marker of in utero cerebral injury or underperfusion.
AB - OBJECTIVE: The objective of the study was to determine the feasibility of detecting fetal brain lactate, a marker of fetal metabolic acidemia, using a noninvasive technique, proton magnetic resonance spectroscopy ( 1H MRS), in intrauterine growth-restricted (IUGR) fetuses. STUDY DESIGN: In vivo human fetal brain lactate detection was determined by 1H MRS in 5 fetuses with IUGR. Oxygenation and acid-base balance data were obtained at birth. RESULTS: 1H MRS analysis showed the presence of a lactate peak in the brain of the most severely affected IUGR fetus, with abnormal umbilical artery Doppler and fetal heart rate tracing. This finding was consistent with the low oxygen content and high lactic acid concentration observed in umbilical blood obtained at delivery. CONCLUSION: 1H MRS allows the noninvasive detection of cerebral lactate in IUGR fetuses. Lactate detected by 1H MRS may represent a possible marker of in utero cerebral injury or underperfusion.
KW - Brain sparing
KW - Fetal brain metabolism
KW - Fetal distress
KW - Placental insufficiency
KW - Pregnancy
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U2 - 10.1016/j.ajog.2011.06.020
DO - 10.1016/j.ajog.2011.06.020
M3 - Article
C2 - 21861968
AN - SCOPUS:84855163794
VL - 205
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 4
ER -