Lactate levels in open interstitial thermal ablation for liver tumors

S. Gruttadauria, C. Doria, A. Luca, G. Vizzini, C. S. Foglieni, V. L. Scott, Ignazio R. Marino

Research output: Contribution to journalArticlepeer-review


Intraoperative radio frequency interstitial thermal ablation (RITA) may result in a reduction of the functional hepatic reserve. To assess this further, we evaluated perioperative lactate levels as a measure of hepatic dysfunction. Sixteen patients scheduled for open RITA (O-RITA) were enrolled in the study. Arterial lactate levels (mmol/L) were measured prior to tumor needle insertion (T0), after O-RITA completion (T1), after wound closure (T2) and 24 hrs after surgery (T3). Correlation between hemodynamic parameters including MAP, and CVP, at T0, T1, T2, T3 and the perioperative rate of lactate production were also analyzed. Total bilirubin, transaminases and international normalized ratio for prothrombin activity (INR) were measured preoperatively and postoperative at day 1, 2, 3 and 7. Data are expressed as mean ± SD and analyzed with ANOVA. Additionally, the Duncan post hoc test was used for multiple comparisons of the differences in mean values. A p-value

Original languageEnglish
Pages (from-to)171-176
Number of pages6
JournalJournal of Experimental and Clinical Cancer Research
Issue number2
Publication statusPublished - 2002


  • Interstitial thermal ablation
  • Liver neoplasm
  • Radio frequency
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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