Lactobacilli and lactoferrin: Biotherapeutic effects for vaginal health

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Protective human vaginal microbiota is characterized by several microbial strains, mainly members of Lactobacillus genus. During vaginal infections, the balance among these strains is altered producing opportunistic or pathogenic bacteria overgrowth. Antibiotic treatments often select for resistant organism or lead to adverse effects on beneficial microbiota. In this study the effect of a combination of L. acidophilus GLA-14 and L. rhamnosus HN001 with lactoferrin, a glycoprotein of the innate immune system exerting antimicrobial, immunomodulatory, and prebiotic actions, has been investigated. Results obtained using a human cervix in vitro model showed that supernatants from both probiotics exert a beneficial effect on cervix cells and that both strains were able to grown in biofilm and exhibited aggregation and adherence properties to biotic or abiotic surfaces. These properties are modulated and even increased by lactoferrin demonstrating the beneficial activity of this biotherapeutic agent combination to prevent and manage urogenital tract infections in women.

Original languageEnglish
Pages (from-to)86-94
Number of pages9
JournalJournal of Functional Foods
Volume45
DOIs
Publication statusPublished - Jun 1 2018

Fingerprint

Lactoferrin
lactoferrin
Microbiota
Lactobacillus
Cervix Uteri
cervix
Prebiotics
Health
Probiotics
Biofilms
Infection
Immune System
Glycoproteins
prebiotics
Anti-Bacterial Agents
Bacteria
infection
biofilm
probiotics
glycoproteins

Keywords

  • Antimicrobial
  • Biofilm
  • Lactobacillus acidophilus
  • Lactobacillus rhamnosus
  • Lactoferrin
  • Vaginal infections

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Lactobacilli and lactoferrin : Biotherapeutic effects for vaginal health. / Bertuccini, Lucia; Russo, Rosario; Iosi, Francesca; Superti, Fabiana.

In: Journal of Functional Foods, Vol. 45, 01.06.2018, p. 86-94.

Research output: Contribution to journalArticle

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abstract = "Protective human vaginal microbiota is characterized by several microbial strains, mainly members of Lactobacillus genus. During vaginal infections, the balance among these strains is altered producing opportunistic or pathogenic bacteria overgrowth. Antibiotic treatments often select for resistant organism or lead to adverse effects on beneficial microbiota. In this study the effect of a combination of L. acidophilus GLA-14 and L. rhamnosus HN001 with lactoferrin, a glycoprotein of the innate immune system exerting antimicrobial, immunomodulatory, and prebiotic actions, has been investigated. Results obtained using a human cervix in vitro model showed that supernatants from both probiotics exert a beneficial effect on cervix cells and that both strains were able to grown in biofilm and exhibited aggregation and adherence properties to biotic or abiotic surfaces. These properties are modulated and even increased by lactoferrin demonstrating the beneficial activity of this biotherapeutic agent combination to prevent and manage urogenital tract infections in women.",
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AU - Superti, Fabiana

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