Lactobacillus reuteri strain combination in helicobacter pylori infection: A randomized, double-blind, placebo-controlled study

Ruggiero Francavilla, Lorenzo Polimeno, Antonella Demichina, Giovanni Maurogiovanni, Beatrice Principi, Giuseppe Scaccianoce, Enzo Ierardi, Francesco Russo, Giuseppe Riezzo, Alfredo Di Leo, Luciano Cavallo, Antonio Francavilla, James Versalovic

Research output: Contribution to journalArticle

Abstract

Goals: The goals of this study were to investigate the role of a new probiotic preparation (Lactobacillus reuteri DSM 17938 and L. reuteri ATCC PTA 6475) in Helicobacter pylori infection. Background: Specific probiotic strains play a role in H. pylori infection for their ability to decrease bacterial load and gastritis, prevent antibiotic-associated side effects, and increase the eradication rate. Study: This is a prospective, double-blind, randomized, placebo-controlled study in a tertiary care setting. A total of 100 H. pylori-positive naive patients received either L. reuteri combination (2×10 Colony Forming Units) or placebo during a 3-phase study (pre-eradication, eradication, and follow-up). All underwent C urea breath test (C-UBT), blood assessments of gastrin-17 (G17), endoscopy, and the Gastrointestinal Symptom Rating Scale. Eradication was confirmed by C-UBT 8 weeks after the completion of therapy. Results: Fifty patients were allocated in each group. During pre-eradication period, C-UBT δ decreased by 13% in L. reuteri combination as compared with a 4% increase in placebo (-13.2±34% vs. 4.3±27%; P

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalJournal of Clinical Gastroenterology
Volume48
Issue number5
DOIs
Publication statusPublished - 2014

Keywords

  • antibiotic-associated side effects
  • bacterial load
  • eradication therapy
  • Helicobacter pylori
  • probiotics

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

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    Francavilla, R., Polimeno, L., Demichina, A., Maurogiovanni, G., Principi, B., Scaccianoce, G., Ierardi, E., Russo, F., Riezzo, G., Di Leo, A., Cavallo, L., Francavilla, A., & Versalovic, J. (2014). Lactobacillus reuteri strain combination in helicobacter pylori infection: A randomized, double-blind, placebo-controlled study. Journal of Clinical Gastroenterology, 48(5), 407-413. https://doi.org/10.1097/MCG.0000000000000007