Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review

Carlo Dani, Caterina Coviello, Iuri Corsini, Fabio Arena, Alberto Antonelli, Gian Maria Rossolini

Research output: Contribution to journalReview article

Abstract

Many term and preterm infants are commonly supplemented with probiotics to prevent adverse effects of antibiotic administration and necrotizing enterocolitis and they are believed to be safe. However, the supplementation with Lactobacillus rhamnosus GG has been associated with the development of sepsis with a cause-effect relationship in six newborns and children. In this study, we report two further cases and discuss the emerging issue of probiotic supplementation safety in neonates. We conclude that physicians must be aware that supplementation with L. rhamnosus GG can cause sepsis in high-risk patients on rare occasions.

Original languageEnglish
Pages (from-to)e25-e29
JournalAJP Reports
Volume6
Issue number1
DOIs
Publication statusPublished - Oct 20 2015

Keywords

  • infant
  • infection
  • lactobacillus
  • probiotics
  • sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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    Dani, C., Coviello, C., Corsini, I., Arena, F., Antonelli, A., & Rossolini, G. M. (2015). Lactobacillus Sepsis and Probiotic Therapy in Newborns: Two New Cases and Literature Review. AJP Reports, 6(1), e25-e29. https://doi.org/10.1055/s-0035-1566312