Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors

Maria Carmina Scala, Marina Sala, Agostina Pietrantoni, Antonia Spensiero, Simone Di Micco, Mariangela Agamennone, Alessia Bertamino, Ettore Novellino, Giuseppe Bifulco, Isabel M. Gomez-Monterrey, Fabiana Superti, Pietro Campiglia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper investigate the ability of lactoferrin derived peptides to inhibit Influenza virus infection, in this study we identified new bovine lactoferrin C-lobe derived sequences and corresponding synthetic peptides were synthesized and assayed to check their ability to prevent viral hemagglutination and infection. We identified three tetrapeptides endowed with broad anti-Influenza activity and able to inhibit viral infection in a concentration range femto- to picomolar. Our data indicate that these peptides may constitute a non-toxic tool for potential applications as anti-Influenza therapeutics.

Original languageEnglish
Article number10593
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Lactoferrin
Human Influenza
Virus Diseases
Peptides
Orthomyxoviridae
Viral Hemagglutination
Hemagglutination
Infection
Innate Immunity
Glycoproteins
Iron
Therapeutics

ASJC Scopus subject areas

  • General

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Lactoferrin-derived Peptides Active towards Influenza : Identification of Three Potent Tetrapeptide Inhibitors. / Scala, Maria Carmina; Sala, Marina; Pietrantoni, Agostina; Spensiero, Antonia; Di Micco, Simone; Agamennone, Mariangela; Bertamino, Alessia; Novellino, Ettore; Bifulco, Giuseppe; Gomez-Monterrey, Isabel M.; Superti, Fabiana; Campiglia, Pietro.

In: Scientific Reports, Vol. 7, No. 1, 10593, 01.12.2017.

Research output: Contribution to journalArticle

Scala, MC, Sala, M, Pietrantoni, A, Spensiero, A, Di Micco, S, Agamennone, M, Bertamino, A, Novellino, E, Bifulco, G, Gomez-Monterrey, IM, Superti, F & Campiglia, P 2017, 'Lactoferrin-derived Peptides Active towards Influenza: Identification of Three Potent Tetrapeptide Inhibitors', Scientific Reports, vol. 7, no. 1, 10593. https://doi.org/10.1038/s41598-017-10492-x
Scala, Maria Carmina ; Sala, Marina ; Pietrantoni, Agostina ; Spensiero, Antonia ; Di Micco, Simone ; Agamennone, Mariangela ; Bertamino, Alessia ; Novellino, Ettore ; Bifulco, Giuseppe ; Gomez-Monterrey, Isabel M. ; Superti, Fabiana ; Campiglia, Pietro. / Lactoferrin-derived Peptides Active towards Influenza : Identification of Three Potent Tetrapeptide Inhibitors. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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