Abstract
Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper investigate the ability of lactoferrin derived peptides to inhibit Influenza virus infection, in this study we identified new bovine lactoferrin C-lobe derived sequences and corresponding synthetic peptides were synthesized and assayed to check their ability to prevent viral hemagglutination and infection. We identified three tetrapeptides endowed with broad anti-Influenza activity and able to inhibit viral infection in a concentration range femto- to picomolar. Our data indicate that these peptides may constitute a non-toxic tool for potential applications as anti-Influenza therapeutics.
| Original language | English |
|---|---|
| Article number | 10593 |
| Journal | Scientific Reports |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Dec 1 2017 |
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Cite this
Lactoferrin-derived Peptides Active towards Influenza : Identification of Three Potent Tetrapeptide Inhibitors. / Scala, Maria Carmina; Sala, Marina; Pietrantoni, Agostina; Spensiero, Antonia; Di Micco, Simone; Agamennone, Mariangela; Bertamino, Alessia; Novellino, Ettore; Bifulco, Giuseppe; Gomez-Monterrey, Isabel M.; Superti, Fabiana; Campiglia, Pietro.
In: Scientific Reports, Vol. 7, No. 1, 10593, 01.12.2017.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Lactoferrin-derived Peptides Active towards Influenza
T2 - Identification of Three Potent Tetrapeptide Inhibitors
AU - Scala, Maria Carmina
AU - Sala, Marina
AU - Pietrantoni, Agostina
AU - Spensiero, Antonia
AU - Di Micco, Simone
AU - Agamennone, Mariangela
AU - Bertamino, Alessia
AU - Novellino, Ettore
AU - Bifulco, Giuseppe
AU - Gomez-Monterrey, Isabel M.
AU - Superti, Fabiana
AU - Campiglia, Pietro
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper investigate the ability of lactoferrin derived peptides to inhibit Influenza virus infection, in this study we identified new bovine lactoferrin C-lobe derived sequences and corresponding synthetic peptides were synthesized and assayed to check their ability to prevent viral hemagglutination and infection. We identified three tetrapeptides endowed with broad anti-Influenza activity and able to inhibit viral infection in a concentration range femto- to picomolar. Our data indicate that these peptides may constitute a non-toxic tool for potential applications as anti-Influenza therapeutics.
AB - Bovine lactoferrin is a biglobular multifunctional iron binding glycoprotein that plays an important role in innate immunity against infections. We have previously demonstrated that selected peptides from bovine lactoferrin C-lobe are able to prevent both Influenza virus hemagglutination and cell infection. To deeper investigate the ability of lactoferrin derived peptides to inhibit Influenza virus infection, in this study we identified new bovine lactoferrin C-lobe derived sequences and corresponding synthetic peptides were synthesized and assayed to check their ability to prevent viral hemagglutination and infection. We identified three tetrapeptides endowed with broad anti-Influenza activity and able to inhibit viral infection in a concentration range femto- to picomolar. Our data indicate that these peptides may constitute a non-toxic tool for potential applications as anti-Influenza therapeutics.
UR - http://www.scopus.com/inward/record.url?scp=85028949949&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028949949&partnerID=8YFLogxK
U2 - 10.1038/s41598-017-10492-x
DO - 10.1038/s41598-017-10492-x
M3 - Article
AN - SCOPUS:85028949949
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 10593
ER -