Lactotransferrin gene functional polymorphisms do not influence susceptibility to human immunodeficiency virus-1 mother-to-child transmission in different ethnic groups

Luisa Zupin, Vania Polesello, Antonio Victor Campos Coelho, Michele Boniotto, Luiz Claudio Arraes, Ludovica Segat, Sergio Crovella

Research output: Contribution to journalArticlepeer-review

Abstract

Lactotransferrin, also known as lactoferrin, is an iron binding glycoprotein that displays antiviral activity against many different infectious agents, including human immunodeficiency virus (HIV)-1. Lactotransferrin is present in the breast milk and in the female genitourinary mucosa and it has been hypothesised as a possible candidate to prevent mother-to-child HIV-1 transmission. To verify if two functional polymorphisms, Thr29Ala and Arg47Lys, in the lactotransferrin encoding gene (LTF) could affect HIV-1 infection and vertical transmission, a preliminary association study was performed in 238 HIV-1 positive and 99 HIV-1 negative children from Brazil, Italy, Africa and India. No statistically significant association for the Thr29Ala and Arg47Lys LTF polymorphisms and HIV-1 susceptibility in the studied populations was found. Additionally LTF polymorphisms frequencies were compared between the four different ethnic groups.

Original languageEnglish
Pages (from-to)222-229
Number of pages8
JournalMemorias do Instituto Oswaldo Cruz
Volume110
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • AIDS
  • HIV-1
  • Innate immunity
  • Lactoferrin
  • SNPs
  • Vertical transmission

ASJC Scopus subject areas

  • Microbiology (medical)

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