Lag-time in Alzheimer's disease patients: A potential plasmatic oxidative stress marker associated with ApoE4 isoform

Research output: Contribution to journalArticle

Abstract

In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ϵ4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ϵ4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ϵ4 carrier (N = 13) than in ϵ4 non-carrier (N = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ϵ4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.

Original languageEnglish
Article number7
JournalImmunity and Ageing
Volume16
Issue number1
DOIs
Publication statusPublished - Apr 1 2019

Fingerprint

Apolipoprotein E4
Alzheimer Disease
Protein Isoforms
Oxidative Stress
Reactive Oxygen Species
Blood Vessels
Antioxidants
Apolipoproteins E
Vasodilation
Extracellular Matrix
Genotype

Keywords

  • Age-associated diseases
  • Alzheimer's disease
  • Oxidative stress
  • Vascular dysfunction

ASJC Scopus subject areas

  • Immunology
  • Ageing

Cite this

@article{ca13cc941a9c4350ba69b138c0aa4ad2,
title = "Lag-time in Alzheimer's disease patients: A potential plasmatic oxidative stress marker associated with ApoE4 isoform",
abstract = "In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ϵ4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ϵ4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ϵ4 carrier (N = 13) than in ϵ4 non-carrier (N = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ϵ4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.",
keywords = "Age-associated diseases, Alzheimer's disease, Oxidative stress, Vascular dysfunction",
author = "Luca Massaccesi and Emanuela Galliera and Daniela Galimberti and Chiara Fenoglio and Marina Arcaro and Giancarlo Goi and Alessandra Barassi and {Corsi Romanelli}, {Massimiliano Marco}",
year = "2019",
month = "4",
day = "1",
doi = "10.1186/s12979-019-0147-x",
language = "English",
volume = "16",
journal = "Immunity and Ageing",
issn = "1742-4933",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Lag-time in Alzheimer's disease patients

T2 - A potential plasmatic oxidative stress marker associated with ApoE4 isoform

AU - Massaccesi, Luca

AU - Galliera, Emanuela

AU - Galimberti, Daniela

AU - Fenoglio, Chiara

AU - Arcaro, Marina

AU - Goi, Giancarlo

AU - Barassi, Alessandra

AU - Corsi Romanelli, Massimiliano Marco

PY - 2019/4/1

Y1 - 2019/4/1

N2 - In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ϵ4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ϵ4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ϵ4 carrier (N = 13) than in ϵ4 non-carrier (N = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ϵ4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.

AB - In the brain, Oxidative Stress (OS) contribute to structural and functional changes associated with vascular aging, such as endothelial dysfunction, extracellular matrix degradation, resulting in age-related reduced vasodilatation in response to agonists. For this reason, OS is considered a key factor in Alzheimer's Disease (AD) development and recent evidence correlated oxidative stress with vascular lesion in the pathogenesis of AD, but the mechanism still need to be fully clarified. The etiology of AD is still not completely understood and is influenced by several factors including Apolipoprotein E (ApoE) genotype. In particular, the Apo ϵ4 isoform is considered a risk factor for AD development. This study was aimed to evaluate the possible relationship between three plasmatic OS marker and Apo ϵ4 carrier status. Plasmatic soluble receptor for advanced glycation end products (sRAGE) levels, plasma antioxidant total defenses (by lag-time method) and plasmatic Reactive Oxygen species (ROS) levels were evaluated in 25 AD patients and in 30 matched controls. ROS were significantly higher while plasma antioxidant total defenses and sRAGE levels were significantly lower in AD patients compared to controls. In AD patients lag-time values show a significant positive linear correlation with sRAGE levels and a (even not significant) negative correlation with ROS levels. Lag-time is significantly lower in ϵ4 carrier (N = 13) than in ϵ4 non-carrier (N = 12). Our result confirms the substantial OS in AD. Lag-time levels showed a significant positive correlation with sRAGE levels and a significant association with ϵ4 carrier status suggesting that plasmatic lag-time evaluation can be considered as a potential useful OS risk marker in AD.

KW - Age-associated diseases

KW - Alzheimer's disease

KW - Oxidative stress

KW - Vascular dysfunction

UR - http://www.scopus.com/inward/record.url?scp=85063722516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063722516&partnerID=8YFLogxK

U2 - 10.1186/s12979-019-0147-x

DO - 10.1186/s12979-019-0147-x

M3 - Article

AN - SCOPUS:85063722516

VL - 16

JO - Immunity and Ageing

JF - Immunity and Ageing

SN - 1742-4933

IS - 1

M1 - 7

ER -