LAK activity is inducible in blood mononuclear cells from human fetus

Andrea Cossarizza, Daniela Monti, Franca Dagna-Bricarelli, Giuliano Montagnani, Claudio Franceschi

Research output: Contribution to journalArticle

Abstract

Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalImmunology Letters
Volume24
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Down's syndrome
  • Human fetal immune system
  • LAK activity
  • NK activity
  • NK cell

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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