TY - JOUR
T1 - LAK activity is inducible in blood mononuclear cells from human fetus
AU - Cossarizza, Andrea
AU - Monti, Daniela
AU - Dagna-Bricarelli, Franca
AU - Montagnani, Giuliano
AU - Franceschi, Claudio
PY - 1990
Y1 - 1990
N2 - Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.
AB - Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.
KW - Down's syndrome
KW - Human fetal immune system
KW - LAK activity
KW - NK activity
KW - NK cell
UR - http://www.scopus.com/inward/record.url?scp=0025374215&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025374215&partnerID=8YFLogxK
U2 - 10.1016/0165-2478(90)90025-L
DO - 10.1016/0165-2478(90)90025-L
M3 - Article
C2 - 2141323
AN - SCOPUS:0025374215
VL - 24
SP - 137
EP - 140
JO - Immunology Letters
JF - Immunology Letters
SN - 0165-2478
IS - 2
ER -