LAK activity is inducible in blood mononuclear cells from human fetus

Andrea Cossarizza; Daniela Monti; Franca Dagna-Bricarelli; Giuliano Montagnani; Claudio Franceschi

doi:10.1016/0165-2478(90)90025-L

LAK activity is inducible in blood mononuclear cells from human fetus

Andrea Cossarizza, Daniela Monti, Franca Dagna-Bricarelli, Giuliano Montagnani, Claudio Franceschi

Istituto Scienze Neurologiche

Research output: Contribution to journal › Article

Abstract

Lymphocyte subpopulations, NK and LAK activities have been studied in blood mononuclear cells from two human fetuses, the first affected by Down's syndrome, the other showing a normal karyotype. Fetuses presented similar subsets, with a scarcity of CD57+ lymphocytes but an appropriate amount of CD16+ and CD56+ cells, while negligible NK activity was detectable. After 18 h of incubation with human recombinant interleukin-2 (rIL-2), significant enhancement of the cytotoxic capability was observed. This stresses the role of IL-2 as a regulatory molecule during the development of the immune system in the human fetus.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Immunology Letters
Volume	24
Issue number	2
DOIs	https://doi.org/10.1016/0165-2478(90)90025-L
Publication status	Published - 1990

Keywords

Down's syndrome
Human fetal immune system
LAK activity
NK activity
NK cell

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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10.1016/0165-2478(90)90025-L

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Cossarizza, A., Monti, D., Dagna-Bricarelli, F., Montagnani, G., & Franceschi, C. (1990). LAK activity is inducible in blood mononuclear cells from human fetus. Immunology Letters, 24(2), 137-140. https://doi.org/10.1016/0165-2478(90)90025-L

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AU - Cossarizza, Andrea

AU - Monti, Daniela

AU - Dagna-Bricarelli, Franca

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AU - Franceschi, Claudio

PY - 1990

Y1 - 1990

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