Lambert-eaton myasthenic syndrome and polyneuropathy in a patient with epidermoid carcinoma of the lung

M. Coinola, R. Nemni, E. Sher, A. Quattrini, A. Faravelli, G. Comi, M. Corbo, F. Dementi, N. Canal

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We describe a patient affected by the Lambert-Eaton myasthenic syndrome. sensory motor axonal neuropathy and epidermoid carcinoma of the lung. Serum autoantibodies to voltage-operated calcium channels were detected. After lobectomy, voltage-operated calcium channel-related structures were demonstrated in the patient's tumor. By immunocytochemistry. the patienfs IgG reacted with neural structures and particularly with intermediate filaments. We think that these autoantibodies may be implicated in the pathogenesis of the neurological symptomatology.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalEuropean Neurology
Volume33
Issue number2
DOIs
Publication statusPublished - 1993

Fingerprint

Lambert-Eaton Myasthenic Syndrome
Polyneuropathies
Calcium Channels
Autoantibodies
Squamous Cell Carcinoma
Lung
Intermediate Filaments
Immunoglobulin G
Immunohistochemistry
Serum
Neoplasms

Keywords

  • Autoantibodies
  • Calcium channels
  • Epidermoid carcinoma
  • Myasthenic syndrome
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Lambert-eaton myasthenic syndrome and polyneuropathy in a patient with epidermoid carcinoma of the lung. / Coinola, M.; Nemni, R.; Sher, E.; Quattrini, A.; Faravelli, A.; Comi, G.; Corbo, M.; Dementi, F.; Canal, N.

In: European Neurology, Vol. 33, No. 2, 1993, p. 121-125.

Research output: Contribution to journalArticle

Coinola, M. ; Nemni, R. ; Sher, E. ; Quattrini, A. ; Faravelli, A. ; Comi, G. ; Corbo, M. ; Dementi, F. ; Canal, N. / Lambert-eaton myasthenic syndrome and polyneuropathy in a patient with epidermoid carcinoma of the lung. In: European Neurology. 1993 ; Vol. 33, No. 2. pp. 121-125.
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AU - Comi, G.

AU - Corbo, M.

AU - Dementi, F.

AU - Canal, N.

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