Lambert-eaton myasthenic syndrome and polyneuropathy in a patient with epidermoid carcinoma of the lung

M. Coinola, R. Nemni, E. Sher, A. Quattrini, A. Faravelli, G. Comi, M. Corbo, F. Dementi, N. Canal

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a patient affected by the Lambert-Eaton myasthenic syndrome. sensory motor axonal neuropathy and epidermoid carcinoma of the lung. Serum autoantibodies to voltage-operated calcium channels were detected. After lobectomy, voltage-operated calcium channel-related structures were demonstrated in the patient's tumor. By immunocytochemistry. the patienfs IgG reacted with neural structures and particularly with intermediate filaments. We think that these autoantibodies may be implicated in the pathogenesis of the neurological symptomatology.

Original languageEnglish
Pages (from-to)121-125
Number of pages5
JournalEuropean Neurology
Volume33
Issue number2
DOIs
Publication statusPublished - 1993

Keywords

  • Autoantibodies
  • Calcium channels
  • Epidermoid carcinoma
  • Myasthenic syndrome
  • Peripheral neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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