Laminin receptors on SCLC cells

E. Tagliabue, S. Martignone, A. Mastroianni, S. Menard, R. Pellegrini, M. I. Colnaghi

Research output: Contribution to journalArticle

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Abstract

Several studies have suggested a correlation between the metastatic potential and the expression of adhesion molecules and/or their receptors on tumour cell surface membranes. In this study we investigated the expression of functional laminin receptors on small cell lung cancer (SCLC) cells. To this aim we set up an adherence assay to determine the in vitro binding capability of tumour cell lines to laminin. All of the three SCLC lines tested and cells from a short-term SCLC line adhered to laminin in cell culture plates, and the affinity of cell-matrix adhesion proved to be higher than the cell-cell adhesion. This effect was always laminin dose-dependent. On a laminin affinity chromatography column three major proteins could be eluted with EDTA from soluble extracts of SCLC lines. Their molecular weights of 120, 90 and 30 kDa suggested a possible relationship with the integrin family. This putative integrin laminin receptor expressed on SCLC does not react with fibronectin, vitronectin or collagen.

Original languageEnglish
Pages (from-to)83-85
Number of pages3
JournalBritish Journal of Cancer
Volume63
Issue numberSUPPL. 14
Publication statusPublished - 1991

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Laminin Receptors
Small Cell Lung Carcinoma
Laminin
Integrins
Cell-Matrix Junctions
Vitronectin
Tumor Cell Line
Affinity Chromatography
Fibronectins
Cell Adhesion
Edetic Acid
Collagen
Cell Culture Techniques
Molecular Weight
Cell Membrane
Neoplasms
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Tagliabue, E., Martignone, S., Mastroianni, A., Menard, S., Pellegrini, R., & Colnaghi, M. I. (1991). Laminin receptors on SCLC cells. British Journal of Cancer, 63(SUPPL. 14), 83-85.

Laminin receptors on SCLC cells. / Tagliabue, E.; Martignone, S.; Mastroianni, A.; Menard, S.; Pellegrini, R.; Colnaghi, M. I.

In: British Journal of Cancer, Vol. 63, No. SUPPL. 14, 1991, p. 83-85.

Research output: Contribution to journalArticle

Tagliabue, E, Martignone, S, Mastroianni, A, Menard, S, Pellegrini, R & Colnaghi, MI 1991, 'Laminin receptors on SCLC cells', British Journal of Cancer, vol. 63, no. SUPPL. 14, pp. 83-85.
Tagliabue E, Martignone S, Mastroianni A, Menard S, Pellegrini R, Colnaghi MI. Laminin receptors on SCLC cells. British Journal of Cancer. 1991;63(SUPPL. 14):83-85.
Tagliabue, E. ; Martignone, S. ; Mastroianni, A. ; Menard, S. ; Pellegrini, R. ; Colnaghi, M. I. / Laminin receptors on SCLC cells. In: British Journal of Cancer. 1991 ; Vol. 63, No. SUPPL. 14. pp. 83-85.
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