Lamotrigine in resistant childhood epilepsy

D. Battino, D. Buti, D. Croci, M. Estienne, A. Fazio, T. Granata, F. Pisani, M. Rota, G. Avanzini

Research output: Contribution to journalArticlepeer-review


Fourteen children (6M, 8F) suffering from refractory epilepsy received LTG as add-on therapy. LTG was administered twice daily at dosages increasing up to 2 mg/kg/day (for patients taking VPA) or to 10 mg/kg/day for patients taking AEDs that induce hepatic metabolism. The drug was withdrawn for side effects in 3 cases (rash: two cases, hirsutism: one), because of increased seizure frequency in 2 cases and because of unchanged seizure frequency in one. One patient died from acute respiratory failure, after repeated respiratory tract infections. A decrease in seizure frequency after one year of treatment with LTG was observed in 6 of the 7 patients who completed the study. The median total seizure frequency decreased from 10.7 ± 7.3 to 3.8 ± 4.6 seizures per day. At the end of the study, seizure frequency had decreased by more than 50% in 2 patients, by more than 75% in 2 patients, and 2 patients were seizure-free; in the remaining patient seizure frequency was unchanged. The best results were obtained with plasma LTG concentrations ranging from 0.5 to 5.4 μg/ml; no further improvement was observed at higher LTG concentrations.

Original languageEnglish
Pages (from-to)332-336
Number of pages5
Issue number6
Publication statusPublished - 1993


  • Anticonvulsants
  • Epilepsy
  • Lamotrigine

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health


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