TY - JOUR
T1 - Monitoraggio delle concentrazioni sieriche di Lamotrigina
T2 - Analisi delle interazioni farmacocinetiche con altri farmaci antiepilettici
AU - Zagnoni, P. G.
AU - Giubergia, S.
AU - Perno, G.
AU - Riva, R.
AU - Albani, F.
AU - Baruzzi, A.
AU - Lunardi, G.
AU - Albano, C.
AU - Abruzzese, M.
AU - Tanganelli, P.
AU - Regesta, G.
AU - Gaggero, R.
AU - Curia, R.
AU - Battino, D.
AU - Estienne, M.
AU - Avanzini, G.
AU - Veggiotti, P.
AU - Gatti, A.
PY - 1996
Y1 - 1996
N2 - The analysis of LTG serum levels in steady-state conditions obtained in 240 adult patients (age range 15-72 yrs) is reported. LTG monatherapy was administered to 27 subjects, while a bitherapy was adminestered to 97 pts (30 pts + VPA, 14 pts + PHT, 38 pts + CBZ, 15 pts + PB/PRI) and LTG politherapy to 116 pts(72 pts + 2 inducing AEDs, 44 pts + 1 ind+VPA). LTG daily doses were higher in subjects treated with inducing AEDs than in those treated with VPA in association, but the corresponding LTG levels were lower than in the former pts. A modest relationship was observed LTG between doses and levels (r = 0,73 in monotherapy) but it was absent during treatment with inducing AEDs. The level/dose ratio varied from 1,3 during monatherapy to 3,1 during association with VPA, while during bi or polytherapy with inducing AEDs changed from 0,6 (+PB/PRI or +CBZ) to 0,4 (+ PHT or + 2 inducing AEDS). From a pharmacokinetic point of view LTG should be administered as single drug or in association with VPA since the association with inducing AEDs leads to low levels.
AB - The analysis of LTG serum levels in steady-state conditions obtained in 240 adult patients (age range 15-72 yrs) is reported. LTG monatherapy was administered to 27 subjects, while a bitherapy was adminestered to 97 pts (30 pts + VPA, 14 pts + PHT, 38 pts + CBZ, 15 pts + PB/PRI) and LTG politherapy to 116 pts(72 pts + 2 inducing AEDs, 44 pts + 1 ind+VPA). LTG daily doses were higher in subjects treated with inducing AEDs than in those treated with VPA in association, but the corresponding LTG levels were lower than in the former pts. A modest relationship was observed LTG between doses and levels (r = 0,73 in monotherapy) but it was absent during treatment with inducing AEDs. The level/dose ratio varied from 1,3 during monatherapy to 3,1 during association with VPA, while during bi or polytherapy with inducing AEDs changed from 0,6 (+PB/PRI or +CBZ) to 0,4 (+ PHT or + 2 inducing AEDS). From a pharmacokinetic point of view LTG should be administered as single drug or in association with VPA since the association with inducing AEDs leads to low levels.
KW - Drug monitoring
KW - Lamotrigine
KW - Pharmacological interactions
UR - http://www.scopus.com/inward/record.url?scp=0030377590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030377590&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:0030377590
SP - 227
EP - 231
JO - Bollettino - Lega Italiana contro l'Epilessia
JF - Bollettino - Lega Italiana contro l'Epilessia
SN - 0394-560X
IS - 95-96
ER -