Langerhans cell histiocytosis and acute leukemia: Unusual association in two cases

M. Arico, A. Comelli, G. Bossi, E. Raiteri, M. Piombo, R. M. Egeler

Research output: Contribution to journalArticlepeer-review

Abstract

Langerhans cell histiocytosis (LCH) is a non-malignant disorder, whether localized or disseminated, and usually has a favourable prognosis. A possible relationship between LCH and neoplastic diseases has not been assessed up to now even if a few cases have been recorded. We report two new cases of acute leukemia in children with LCH. The first child had acute lymphoblastic leukemia after untreated LCH; the second developed acute promyelocytic leukemia after LCH treated with vinblastine and etoposide. To our knowledge, this is the first case of secondary leukemia after exposure to an epipodophyllotoxin derivative in a child with benign disease. Cooperative studies of large numbers of LCH patients are needed to evaluate a possible association between LCH and acute leukemia, and to identify common risk factors or predisposing agents if such be present.

Original languageEnglish
Pages (from-to)271-273
Number of pages3
JournalMedical and Pediatric Oncology
Volume21
Issue number4
Publication statusPublished - 1993

Keywords

  • acute leukemia
  • childhood
  • Langerhans cell histiocytosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Langerhans cell histiocytosis and acute leukemia: Unusual association in two cases'. Together they form a unique fingerprint.

Cite this