Langerhans cell histiocytosis arising after Hodgkin's disease

Andrea Ferrari, Paola Fabietti, Graziella Vessecchia, Alberto Laffranchi, Luciano Lombardi, Maura Massimino, Franca Fossati-Bellani, Roberto Giardini

Research output: Contribution to journalArticlepeer-review


We present the case of a 19-year-old male who suffered from Langerhans cell histiocytosis (LCH) 12 months after having been treated for recurrent Hodgkin's disease (HD). Immunophenotypic characterization and electron microscopic analysis were useful for the exclusion of a bone relapse of Hodgkin's disease or any other differential diagnosis. The association of LCH with HD or other malignancies is rare but more frequent than previously believed. The significance of such an association and the pathophysiology of LCH are still open questions.

Original languageEnglish
Pages (from-to)585-588
Number of pages4
JournalPediatric Hematology and Oncology
Issue number6
Publication statusPublished - Nov 1997


  • Hodgkin's disease
  • Langerhans cell histiocytosis
  • Second primary

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology
  • Cancer Research
  • Management of Technology and Innovation


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