Langerhans cell histiocytosis (LCH): Guidelines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years

Riccardo Haupt, Milen Minkov, Itziar Astigarraga, Eva Schäfer, Vasanta Nanduri, Rima Jubran, R. Maarten Egeler, Gritta Janka, Dragan Micic, Carlos Rodriguez-Galindo, Stefaan Van Gool, Johannes Visser, Sheila Weitzman, Jean Donadieu

Research output: Contribution to journalArticlepeer-review

Abstract

These guidelines for the management of patients up to 18 years with Langerhans cell histiocytosis (LCH) have been set up by a group of experts involved in the Euro Histio Net project who participated in national or international studies and in peer reviewed publications. Existing guidelines were reviewed and changed where new evidence was available in the literature up to 2012. Data and publications have been ranked according to evidence based medicine and when there was a lack of published data, consensus between experts was sought. Guidelines for diagnosis, initial clinical work-up, and treatment and long-term follow-up of LCH patients are presented.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalPediatric Blood and Cancer
Volume60
Issue number2
DOIs
Publication statusPublished - Feb 2013

Keywords

  • Clinical work-up
  • Diagnosis
  • Follow-up
  • Guidelines
  • Langerhans cell histiocytosis
  • Therapy

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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