Language recovery following subthalamic nucleus stimulation in Parkinson's disease

Sergio Zanini, Alessandro Melatini, Livio Capus, Manuela Gioulis, Antonio Vassallo, Antonio Bava

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Neuropsychological consequences of stimulation of the subthalamic nucleus for treatment of drug-resistant Parkinson's disease (PD) have been studied previously. However, no detailed investigations of linguistic function modifications have been carried out. We studied four consecutive patients with PD who underwent chronic bilateral stimulation of the subthalamic nuclei. Neuropsychological and linguistic evaluations were performed before and 2 weeks after surgery. Linguistic abilities were studied also 1 year after surgery with stimulators both off and on. Intraphrasal hesitation pauses, phonemic paraphasias and morpho-syntactic errors were significantly reduced and lexical retrieval improved with stimulation of the subthalamic nuclei. Implicit linguistic phenomena, mainly occurring within basal ganglia circuitry, benefited by recovery of functional equilibrium within basal nuclei and between overall basal ganglia circuitry and cerebral cortex.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalNeuroReport
Volume14
Issue number3
Publication statusPublished - Mar 3 2003

Fingerprint

Subthalamic Nucleus
Linguistics
Parkinson Disease
Language
Basal Ganglia
Aptitude
Cerebral Cortex
Pharmaceutical Preparations
Therapeutics

Keywords

  • Deep brain stimulation
  • Implicit memory
  • Language
  • Parkinson's disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Zanini, S., Melatini, A., Capus, L., Gioulis, M., Vassallo, A., & Bava, A. (2003). Language recovery following subthalamic nucleus stimulation in Parkinson's disease. NeuroReport, 14(3), 511-516.

Language recovery following subthalamic nucleus stimulation in Parkinson's disease. / Zanini, Sergio; Melatini, Alessandro; Capus, Livio; Gioulis, Manuela; Vassallo, Antonio; Bava, Antonio.

In: NeuroReport, Vol. 14, No. 3, 03.03.2003, p. 511-516.

Research output: Contribution to journalArticle

Zanini, S, Melatini, A, Capus, L, Gioulis, M, Vassallo, A & Bava, A 2003, 'Language recovery following subthalamic nucleus stimulation in Parkinson's disease', NeuroReport, vol. 14, no. 3, pp. 511-516.
Zanini S, Melatini A, Capus L, Gioulis M, Vassallo A, Bava A. Language recovery following subthalamic nucleus stimulation in Parkinson's disease. NeuroReport. 2003 Mar 3;14(3):511-516.
Zanini, Sergio ; Melatini, Alessandro ; Capus, Livio ; Gioulis, Manuela ; Vassallo, Antonio ; Bava, Antonio. / Language recovery following subthalamic nucleus stimulation in Parkinson's disease. In: NeuroReport. 2003 ; Vol. 14, No. 3. pp. 511-516.
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