Abstract
We report a boy, referred at 25months following a dramatic isolated language regression antedating autistic-like symptomatology.His sleep electroencephalogram (EEG) showed persistent focal epileptiform activity over the left parietal and vertex areas never associated with clinical seizures. He was started on adrenocorticotropic hormone (ACTH) with a significant improvement in language, behavior, and in EEG discharges in rapid eye movement (REM) sleep. Later course was characterized by fluctuations/ regressions in language and behavior abilities, in phase with recrudescence of EEG abnormalities prompting additional ACTH courses that led to remarkable decrease in EEG abnormalities, improvement in language, and to a lesser degree, in autistic behavior. The timely documentation of regression episodes suggesting an atypical autistic regression, striking therapyinduced improvement, fluctuation of symptomatology over time could be ascribed to recurrent and persisting EEG abnormalities.
| Original language | English |
|---|---|
| Pages (from-to) | 855-859 |
| Number of pages | 5 |
| Journal | Journal of Child Neurology |
| Volume | 29 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Adrenocorticotropic hormone (ACTH)
- Autistic
- Epileptiform activity
- Language
- Long-term outcome
ASJC Scopus subject areas
- Clinical Neurology
- Pediatrics, Perinatology, and Child Health
- Medicine(all)
Cite this
Language regression associated with autistic regression and electroencephalographic (eeg) abnormalities : A prospective study. / Chilosi, Anna Maria; Brovedani, Paola; Ferrari, Anna Rita; Ziegler, Anne Lise; Guerrini, Renzo; Deonna, Thierry.
In: Journal of Child Neurology, Vol. 29, No. 6, 2014, p. 855-859.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Language regression associated with autistic regression and electroencephalographic (eeg) abnormalities
T2 - A prospective study
AU - Chilosi, Anna Maria
AU - Brovedani, Paola
AU - Ferrari, Anna Rita
AU - Ziegler, Anne Lise
AU - Guerrini, Renzo
AU - Deonna, Thierry
PY - 2014
Y1 - 2014
N2 - We report a boy, referred at 25months following a dramatic isolated language regression antedating autistic-like symptomatology.His sleep electroencephalogram (EEG) showed persistent focal epileptiform activity over the left parietal and vertex areas never associated with clinical seizures. He was started on adrenocorticotropic hormone (ACTH) with a significant improvement in language, behavior, and in EEG discharges in rapid eye movement (REM) sleep. Later course was characterized by fluctuations/ regressions in language and behavior abilities, in phase with recrudescence of EEG abnormalities prompting additional ACTH courses that led to remarkable decrease in EEG abnormalities, improvement in language, and to a lesser degree, in autistic behavior. The timely documentation of regression episodes suggesting an atypical autistic regression, striking therapyinduced improvement, fluctuation of symptomatology over time could be ascribed to recurrent and persisting EEG abnormalities.
AB - We report a boy, referred at 25months following a dramatic isolated language regression antedating autistic-like symptomatology.His sleep electroencephalogram (EEG) showed persistent focal epileptiform activity over the left parietal and vertex areas never associated with clinical seizures. He was started on adrenocorticotropic hormone (ACTH) with a significant improvement in language, behavior, and in EEG discharges in rapid eye movement (REM) sleep. Later course was characterized by fluctuations/ regressions in language and behavior abilities, in phase with recrudescence of EEG abnormalities prompting additional ACTH courses that led to remarkable decrease in EEG abnormalities, improvement in language, and to a lesser degree, in autistic behavior. The timely documentation of regression episodes suggesting an atypical autistic regression, striking therapyinduced improvement, fluctuation of symptomatology over time could be ascribed to recurrent and persisting EEG abnormalities.
KW - Adrenocorticotropic hormone (ACTH)
KW - Autistic
KW - Epileptiform activity
KW - Language
KW - Long-term outcome
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UR - http://www.scopus.com/inward/citedby.url?scp=84903531107&partnerID=8YFLogxK
U2 - 10.1177/0883073813482767
DO - 10.1177/0883073813482767
M3 - Article
C2 - 23562946
AN - SCOPUS:84903531107
VL - 29
SP - 855
EP - 859
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 6
ER -