Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake

Chiara Lanzani, Guido Gatti, Lorena Citterio, Elisabetta Messaggio, Simona Delli Carpini, Marco Simonini, Nunzia Casamassima, Laura Zagato, Elena Brioni, John M. Hamlyn, Paolo Manunta

Research output: Contribution to journalArticle

Abstract

Circulating levels of endogenous ouabain (EO), a vasopressor hormone of adrenocortical origin, are increased by sodium depletion. Furthermore, lanosterol synthase, an enzyme involved in cholesterol biosynthesis, has a missense polymorphism (rs2254524 V642L) that affects EO biosynthesis in adrenocortical cells. Here, we investigated the hypothesis that lanosterol synthase rs2254524 alleles in vivo impact the blood pressure (BP) and EO responses evoked by a low dietary Na intake (

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalHypertension
Volume67
Issue number2
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Diet
  • digitalis-like factors
  • genetic polymorphisms
  • hypertension
  • Na-K ATPase

ASJC Scopus subject areas

  • Internal Medicine

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    Lanzani, C., Gatti, G., Citterio, L., Messaggio, E., Delli Carpini, S., Simonini, M., Casamassima, N., Zagato, L., Brioni, E., Hamlyn, J. M., & Manunta, P. (2016). Lanosterol Synthase Gene Polymorphisms and Changes in Endogenous Ouabain in the Response to Low Sodium Intake. Hypertension, 67(2), 342-348. https://doi.org/10.1161/HYPERTENSIONAHA.115.06415