Laparoendoscopic rendezvous reduces perioperative morbidity and risk of pancreatitis

Alberto Arezzo, Nereo Vettoretto, Federico Famiglietti, Lorenzo Moja, Mario Morino

Research output: Contribution to journalArticlepeer-review


Background: The ideal management of cholelithiasis and common bile duct stones still is controversial. Although the two-stage sequential approach remains the prevalent management, several trials have concluded that the so-called laparoendoscopic rendezvous (LERV) technique offers some advantages, such as a reduced risk of post-ERCP (endoscopic retrograde cholangiopancreatography) pancreatitis. This study aimed to compare the single-stage LERV technique with the two-stage endoscopic sphincterotomy followed by laparoscopic cholecystectomy. Methods: A search for randomized controlled trials (RCTs) comparing LERV and the two-stage sequential approach was conducted. The outcomes considered were overall complications and pancreatitis. Medline, EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched from 1998 to July 2012. Odds ratios (ORs) were extracted and pooled using a fixed or random-effect model depending on I 2 used as a heterogeneity measure. Results: Four RCTs, including a total of 430 patients, met the inclusion criteria. The incidence of overall complications was lower in the LERV group (11.2 %) than in the two-stage intervention group (18.1 %) (OR, 0.56; 95 % confidence interval [CI], 0.32-0.99; P = 0.04; I 2 = 45 %). The findings showed that LERV was associated with less clinical pancreatitis (2.4 %) than the two-stage technique (8.4 %) (OR, 0.33; 95 % CI, 0.12-0.91; P = 0.03; I 2 = 33 %). Conclusions: Despite the limitation of a small number of studies completed, the evidence of RCTs shows that LERV is superior to two-stage treatment due to a reduction in overall complications, particularly pancreatitis.

Original languageEnglish
Pages (from-to)1055-1060
Number of pages6
JournalSurgical Endoscopy and Other Interventional Techniques
Issue number4
Publication statusPublished - Apr 2013


  • Common bile duct
  • Gallbladder
  • Laparoendoscopic rendezvous
  • Metaanalysis
  • Stones
  • Systematic review

ASJC Scopus subject areas

  • Surgery


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