Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis

G. Belli, P. Limongelli, C. Fantini, A. D'Agostino, L. Cioffi, A. Belli, G. Russo

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Background: Few studies have compared survival and recurrence rates between laparoscopic and open liver resection for hepatocellular carcinoma in patients with cirrhosis. Methods: A retrospective analysis of a prospectively maintained database of 179 liver resections performed for HCC in cirrhotic liver between 2000 and 2007 was performed. Results: Fifty-four patients underwent a laparoscopic resection and 125 patients had open surgery. Histopathological features were largely comparable in the two groups. Tumours operated laparoscopically were smaller than those removed at open operation and laparoscopic liver resection was less extensive. Laparoscopic surgery had a lower morbidity rate than open surgery (19 versus 36.0 per cent; P = 0.020), whereas 30-day mortality was similar (2 versus 4.0 per cent; P = 0.615). After a median follow-up of 24 months, 1- and 3-year survival rates were 94 and 67 per cent in the laparoscopic group. Recurrence rates were similar after laparoscopic and open procedures (45 versus 52.5 per cent; P = 0.381), as was disease-free survival (P = 0.864). Conclusion: Laparoscopic resection of HCC in cirrhotic liver is feasible and safe in selected patients. Adequate long-term survival and recurrence is achieved compared with open surgery, when stratified for tumour characteristics known to be related to survival outcome.

Original languageEnglish
Pages (from-to)1041-1048
Number of pages8
JournalBritish Journal of Surgery
Volume96
Issue number9
DOIs
Publication statusPublished - Sep 2009

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Hepatocellular Carcinoma
Fibrosis
Liver
Recurrence
Survival Rate
Therapeutics
Survival
Laparoscopy
Disease-Free Survival
Neoplasms
Databases
Morbidity
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Belli, G., Limongelli, P., Fantini, C., D'Agostino, A., Cioffi, L., Belli, A., & Russo, G. (2009). Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. British Journal of Surgery, 96(9), 1041-1048. https://doi.org/10.1002/bjs.6680

Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. / Belli, G.; Limongelli, P.; Fantini, C.; D'Agostino, A.; Cioffi, L.; Belli, A.; Russo, G.

In: British Journal of Surgery, Vol. 96, No. 9, 09.2009, p. 1041-1048.

Research output: Contribution to journalArticle

Belli, G, Limongelli, P, Fantini, C, D'Agostino, A, Cioffi, L, Belli, A & Russo, G 2009, 'Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis', British Journal of Surgery, vol. 96, no. 9, pp. 1041-1048. https://doi.org/10.1002/bjs.6680
Belli G, Limongelli P, Fantini C, D'Agostino A, Cioffi L, Belli A et al. Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. British Journal of Surgery. 2009 Sep;96(9):1041-1048. https://doi.org/10.1002/bjs.6680
Belli, G. ; Limongelli, P. ; Fantini, C. ; D'Agostino, A. ; Cioffi, L. ; Belli, A. ; Russo, G. / Laparoscopic and open treatment of hepatocellular carcinoma in patients with cirrhosis. In: British Journal of Surgery. 2009 ; Vol. 96, No. 9. pp. 1041-1048.
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