Laparoscopia vs approccio aperto in chirurgia colorettale: Morbidità postoperatoria in un trial randomizzato monocentrico

M. Frasson; M. Braga; A. Vignali; W. Zuliani; P. Gruarin; P. Dellabona; V. Di Carlo

Laparoscopia vs approccio aperto in chirurgia colorettale: Morbidità postoperatoria in un trial randomizzato monocentrico

Translated title of the contribution: Laparoscopic-assisted versus open surgery for colorectal cancer: Postoperative morbidity in a single center randomized trial

M. Frasson, M. Braga, A. Vignali, W. Zuliani, P. Gruarin, P. Dellabona, V. Di Carlo

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Aim. The primary objective of the study-was to compare the effect of laparoscopic-assisted (LPS) versus open surgery (LPT) for colorectal cancer on postoperative morbidity. The secondary objectives were to evaluate immune response and intestinal wall oxygen perfusion. Methods. A total of 610 patients with colorectal cancer were randomly assigned to receive colon resection by either LPS (n=306) or LPT (n=304). Four surgical staff members not involved in the study recorded postoperative complications up to 30 days after the operation. Immune response was evaluated by measuring lymphocytic proliferation after challenge with Candida albicans and phytohemoagglutinin before, at 3 and 15 days after the operation. Intestinal wall oxygen perfusion was continuously monitored using a probe. Results. The conversion rate was 4.6% in the LPS group. Morbidity was 18.6% in the LPS group and 34.5% in the LPT group (P

Translated title of the contribution	Laparoscopic-assisted versus open surgery for colorectal cancer: Postoperative morbidity in a single center randomized trial
Original language	Italian
Pages (from-to)	283-292
Number of pages	10
Journal	Minerva Chirurgica
Volume	61
Issue number	4
Publication status	Published - Aug 2006

ASJC Scopus subject areas

Surgery

Cite this

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title = "Laparoscopia vs approccio aperto in chirurgia colorettale: Morbidit{\`a} postoperatoria in un trial randomizzato monocentrico",

abstract = "Aim. The primary objective of the study-was to compare the effect of laparoscopic-assisted (LPS) versus open surgery (LPT) for colorectal cancer on postoperative morbidity. The secondary objectives were to evaluate immune response and intestinal wall oxygen perfusion. Methods. A total of 610 patients with colorectal cancer were randomly assigned to receive colon resection by either LPS (n=306) or LPT (n=304). Four surgical staff members not involved in the study recorded postoperative complications up to 30 days after the operation. Immune response was evaluated by measuring lymphocytic proliferation after challenge with Candida albicans and phytohemoagglutinin before, at 3 and 15 days after the operation. Intestinal wall oxygen perfusion was continuously monitored using a probe. Results. The conversion rate was 4.6% in the LPS group. Morbidity was 18.6% in the LPS group and 34.5% in the LPT group (P",

keywords = "Colonic neoplasms, surgery, Laparoscopy, Oxigen tension, Postoperative complications, Rectal neoplasms, surgery",

author = "M. Frasson and M. Braga and A. Vignali and W. Zuliani and P. Gruarin and P. Dellabona and {Di Carlo}, V.",

year = "2006",

month = aug,

language = "Italian",

volume = "61",

pages = "283--292",

journal = "Minerva Chirurgica",

issn = "0026-4733",

publisher = "Edizioni Minerva Medica S.p.A.",

number = "4",

}

TY - JOUR

T1 - Laparoscopia vs approccio aperto in chirurgia colorettale

T2 - Morbidità postoperatoria in un trial randomizzato monocentrico

AU - Frasson, M.

AU - Braga, M.

AU - Vignali, A.

AU - Zuliani, W.

AU - Gruarin, P.

AU - Dellabona, P.

AU - Di Carlo, V.

PY - 2006/8

Y1 - 2006/8

N2 - Aim. The primary objective of the study-was to compare the effect of laparoscopic-assisted (LPS) versus open surgery (LPT) for colorectal cancer on postoperative morbidity. The secondary objectives were to evaluate immune response and intestinal wall oxygen perfusion. Methods. A total of 610 patients with colorectal cancer were randomly assigned to receive colon resection by either LPS (n=306) or LPT (n=304). Four surgical staff members not involved in the study recorded postoperative complications up to 30 days after the operation. Immune response was evaluated by measuring lymphocytic proliferation after challenge with Candida albicans and phytohemoagglutinin before, at 3 and 15 days after the operation. Intestinal wall oxygen perfusion was continuously monitored using a probe. Results. The conversion rate was 4.6% in the LPS group. Morbidity was 18.6% in the LPS group and 34.5% in the LPT group (P

AB - Aim. The primary objective of the study-was to compare the effect of laparoscopic-assisted (LPS) versus open surgery (LPT) for colorectal cancer on postoperative morbidity. The secondary objectives were to evaluate immune response and intestinal wall oxygen perfusion. Methods. A total of 610 patients with colorectal cancer were randomly assigned to receive colon resection by either LPS (n=306) or LPT (n=304). Four surgical staff members not involved in the study recorded postoperative complications up to 30 days after the operation. Immune response was evaluated by measuring lymphocytic proliferation after challenge with Candida albicans and phytohemoagglutinin before, at 3 and 15 days after the operation. Intestinal wall oxygen perfusion was continuously monitored using a probe. Results. The conversion rate was 4.6% in the LPS group. Morbidity was 18.6% in the LPS group and 34.5% in the LPT group (P

KW - Colonic neoplasms, surgery

KW - Laparoscopy

KW - Oxigen tension

KW - Postoperative complications

KW - Rectal neoplasms, surgery

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M3 - Articolo

C2 - 17122760

AN - SCOPUS:33846509875

VL - 61

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JO - Minerva Chirurgica

JF - Minerva Chirurgica

SN - 0026-4733

IS - 4

ER -

Laparoscopia vs approccio aperto in chirurgia colorettale: Morbidità postoperatoria in un trial randomizzato monocentrico

Abstract

ASJC Scopus subject areas

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