Laparoscopic indocyanine green sentinel lymph node mapping in early ovarian cancer. A pilot study and review of the literature

Michela Angelucci, Giacomo Corrado, Emanuela Mancini, Ermelinda Baiocco, Benito Chiofalo, Ashanti Zampa, Arabella Bufalo, Enrico Vizza

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Objective: there are still few studies concerning the Sentinel lymph node (SLN) in ovarian cancer. In this pilot study we described the feasibility of SLN mapping with Indocyanine Green (ICG) in five patients affected by early stage ovarian cancer, during laparoscopic surgery. Material and Methods: the tracer has been injected into the hilum of the ovary through a spinal needle (22-gauge size) connected to 20 cm-long infusion tubing for intravenous fluid delivery advanced inside the lateral trocar (10 mm) through a Johann clamp. Results: a total of 6 SNs was detected in all patients. The median interval from the tracer injection to the detection of all SNs was 2 minutes (range, 1 - 3 minutes). In three patients, the first detected SN was found in the area of common iliac artery, in two patients at paracaval region. The median number of lymph nodes removed per patient was 2 (range, 0-2). All the detected SLNs were identified ipsilateral to the site of injection. Only in two patients we detected a second SLN, respectively in preaortic region and in under mesenteric region. No allergic reaction has occurred. Conclusions: ICG laparoscopic SLN mapping in early stage ovarian cancer is a procedure feasible and promising. Additional prospective multicenter studies are needed to evaluate the best technique for staging early stage ovarian cancer patients.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalItalian Journal of Gynaecology and Obstetrics
Volume28
Issue number5
DOIs
Publication statusPublished - Dec 1 2016

Fingerprint

Indocyanine Green
Ovarian Neoplasms
Injections
Iliac Artery
Sentinel Lymph Node
Surgical Instruments
Intravenous Infusions
Laparoscopy
Multicenter Studies
Needles
Ovary
Hypersensitivity
Lymph Nodes
Prospective Studies

Keywords

  • Indocyanine green
  • Ovarian cancer
  • Sentinel lymph node biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Laparoscopic indocyanine green sentinel lymph node mapping in early ovarian cancer. A pilot study and review of the literature. / Angelucci, Michela; Corrado, Giacomo; Mancini, Emanuela; Baiocco, Ermelinda; Chiofalo, Benito; Zampa, Ashanti; Bufalo, Arabella; Vizza, Enrico.

In: Italian Journal of Gynaecology and Obstetrics, Vol. 28, No. 5, 01.12.2016, p. 23-28.

Research output: Contribution to journalReview article

Angelucci, Michela ; Corrado, Giacomo ; Mancini, Emanuela ; Baiocco, Ermelinda ; Chiofalo, Benito ; Zampa, Ashanti ; Bufalo, Arabella ; Vizza, Enrico. / Laparoscopic indocyanine green sentinel lymph node mapping in early ovarian cancer. A pilot study and review of the literature. In: Italian Journal of Gynaecology and Obstetrics. 2016 ; Vol. 28, No. 5. pp. 23-28.
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AU - Angelucci, Michela

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AU - Mancini, Emanuela

AU - Baiocco, Ermelinda

AU - Chiofalo, Benito

AU - Zampa, Ashanti

AU - Bufalo, Arabella

AU - Vizza, Enrico

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