Laparoscopic intragastric resection of melanoma cardial lesion

Stefano Rausei, Vincenzo Pappalardo, Luigi Boni, Gianlorenzo Dionigi

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Gastrointestinal tract involvements of metastatic melanoma are rare; 7% of gastrointestinal tract metastases of melanoma concerns the stomach [1]. Actually, bleeding from gastric melanoma metastasis is very rare. For the first time in Literature, this video shows a laparoscopic intragastric resection [2] of a cardial lesion of melanoma. A 64-year old patient with history of a skin melanoma resection with lung and liver metastatic disease confirmed by FDG PET, stable after repeated cycles of Pembrolizumab, presented anemia with gastrointestinal bleeding signs. Endoscopy and CT scans documented a 4-cm subcardial metastatic melanoma lesion. Endoscopic ultrasound evaluation confirmed no full-thickness involvement of gastric wall. Patient refused blood transfusions because Jehovah's Witness. Since the tumor position so close to the cardias contraindicated both typical endoscopic and laparoscopic approaches, we proposed laparoscopic intragastric solution in order to avoid risk related to a total gastrectomy. METHODS: Procedure was performed by 3 intragastric trocars placed under endoscopic view. The primary surgical intent was to excise the tumor in order to avoid further bleeding. Actually, during dissection we verified the possibility to radically resect the lesion. After removal (with partial fragmentation) of the lesion, residual free fragments have been accurately removed to reduce the risks of tumor implantation on gastric mucosa and a mucosal suture was completed. Two-layer running sutures were applied on gastric holes. After completion of procedure, suture and cardial gastric wall were tested for leakage with satisfying result. Finally, lesser sac was opened up to expose the right diaphragmatic pillar in order to exclude eventual posterior gastric wall damage. RESULTS: Pathologic evaluation demonstrated a diffuse submucosal invasion by melanoma, confirming that R0 resection was achieved. CONCLUSIONS: In the general strategy of a palliation treatment of a largely metastastic tumor, the specific aim of this procedure was to stop gastric bleeding and to allow the continuation of systemic therapies effective in the disease control. After 6 months from surgery, patient resumed chemotherapy without any documented gastric recurrence.

Original languageEnglish
Number of pages1
JournalSurgical Oncology
Volume27
Issue number4
DOIs
Publication statusPublished - Dec 1 2018

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Melanoma
Stomach
Sutures
Hemorrhage
Gastrointestinal Tract
Neoplasms
Jehovah's Witnesses
Neoplasm Metastasis
Cardia
Peritoneal Cavity
Gastrectomy
Gastric Mucosa
Surgical Instruments
Blood Transfusion
Endoscopy
Dissection
Liver Diseases
Anemia
Recurrence
Drug Therapy

Keywords

  • Gastric melanoma
  • Laparoscopic intragastric resection
  • Laparoscopic surgery

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Laparoscopic intragastric resection of melanoma cardial lesion. / Rausei, Stefano; Pappalardo, Vincenzo; Boni, Luigi; Dionigi, Gianlorenzo.

In: Surgical Oncology, Vol. 27, No. 4, 01.12.2018.

Research output: Contribution to journalArticle

Rausei, Stefano ; Pappalardo, Vincenzo ; Boni, Luigi ; Dionigi, Gianlorenzo. / Laparoscopic intragastric resection of melanoma cardial lesion. In: Surgical Oncology. 2018 ; Vol. 27, No. 4.
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