Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry

I Go MILS Group on HCC

Research output: Contribution to journalArticle

Abstract

Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.

Original languageEnglish
JournalSurgical Endoscopy and Other Interventional Techniques
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Propensity Score
Minimally Invasive Surgical Procedures
Registries
Hepatocellular Carcinoma
Liver
Operative Time
Laparoscopy
Morbidity
Mortality

Keywords

  • Child B
  • Hepatocellular carcinoma
  • IGoMILS
  • Laparoscopic HCC
  • Laparoscopic liver resection
  • Posterior segment

ASJC Scopus subject areas

  • Surgery

Cite this

@article{413a44f5616946dca749b21b7abe5710,
title = "Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments: a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry",
abstract = "Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.",
keywords = "Child B, Hepatocellular carcinoma, IGoMILS, Laparoscopic HCC, Laparoscopic liver resection, Posterior segment",
author = "{I Go MILS Group on HCC} and {Levi Sandri}, {Giovanni Battista} and Ettorre, {Giuseppe Maria} and Luca Aldrighetti and Umberto Cillo and {Dalla Valle}, Raffaele and Alfredo Guglielmi and Vincenzo Mazzaferro and Alessandro Ferrero and {Di Benedetto}, Fabrizio and Salvatore Gruttadauria and {De Carlis}, Luciano and Giovanni Vennarecci and Adelmo Antonucci and Giulio Belli and Stefano Berti and Ugo Boggi and Pasquale Bonsignore and Alberto Brolese and Fulvio Calise and Graziano Ceccarelli and Michele Colledan and Andrea Coratti and Fabio Ferla and Antonio Floridi and Antonio Frena and Antonio Giuliani and Felice Giuliante and Grazi, {Gian Luca} and Enrico Gringeri and Guido Griseri and Maurizio Iaria and Elio Jovine and Paolo Magistri and Pietro Maida and Pietro Mezzatesta and Nadia Russolillo and Giuseppe Navarra and Amilcare Parisi and Pinna, {Antonio Daniele} and Francesca Ratti and Rossi, {Giorgio Ettore} and Andrea Ruzzenente and Roberto Santambrogio and Andrea Scotti and Giovanni Sgroi and Abdallah Slim and Guido Torzilli and Leonardo Vincenti and Matteo Virdis and Fausto Zamboni",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/s00464-018-6426-3",
language = "English",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York",

}

TY - JOUR

T1 - Laparoscopic liver resection of hepatocellular carcinoma located in unfavorable segments

T2 - a propensity score-matched analysis from the I Go MILS (Italian Group of Minimally Invasive Liver Surgery) Registry

AU - I Go MILS Group on HCC

AU - Levi Sandri, Giovanni Battista

AU - Ettorre, Giuseppe Maria

AU - Aldrighetti, Luca

AU - Cillo, Umberto

AU - Dalla Valle, Raffaele

AU - Guglielmi, Alfredo

AU - Mazzaferro, Vincenzo

AU - Ferrero, Alessandro

AU - Di Benedetto, Fabrizio

AU - Gruttadauria, Salvatore

AU - De Carlis, Luciano

AU - Vennarecci, Giovanni

AU - Antonucci, Adelmo

AU - Belli, Giulio

AU - Berti, Stefano

AU - Boggi, Ugo

AU - Bonsignore, Pasquale

AU - Brolese, Alberto

AU - Calise, Fulvio

AU - Ceccarelli, Graziano

AU - Colledan, Michele

AU - Coratti, Andrea

AU - Ferla, Fabio

AU - Floridi, Antonio

AU - Frena, Antonio

AU - Giuliani, Antonio

AU - Giuliante, Felice

AU - Grazi, Gian Luca

AU - Gringeri, Enrico

AU - Griseri, Guido

AU - Iaria, Maurizio

AU - Jovine, Elio

AU - Magistri, Paolo

AU - Maida, Pietro

AU - Mezzatesta, Pietro

AU - Russolillo, Nadia

AU - Navarra, Giuseppe

AU - Parisi, Amilcare

AU - Pinna, Antonio Daniele

AU - Ratti, Francesca

AU - Rossi, Giorgio Ettore

AU - Ruzzenente, Andrea

AU - Santambrogio, Roberto

AU - Scotti, Andrea

AU - Sgroi, Giovanni

AU - Slim, Abdallah

AU - Torzilli, Guido

AU - Vincenti, Leonardo

AU - Virdis, Matteo

AU - Zamboni, Fausto

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.

AB - Objective: Laparoscopic liver resection (LLR) for Hepatocellular Carcinoma (HCC) is one of the most important indications for the minimally invasive approach. Our study aims to analyze the experience of the Italian Group of Minimally Invasive Liver Surgery with laparoscopic surgical treatment of HCC, with a focus on tumor location and how it affects morbidity and mortality. Methods: 38 centers participated in this study; 372 cases of LLR for HCC were prospectively enrolled. Patients were divided into two groups according to the HCC nodule location. Group 1 favorable location and group 2 unfavorable location. Perioperative outcomes were compared between the two groups before and after a propensity score match (PS) 1:1. Results: Before PS in group 2 surgical time was longer; conversion rate was higher; postoperative transfusion and comprehensive complication index were also higher. PS was performed with a cohort of 298 patients (from 18 centers), with 66 and 232 patients with HCC in unfavorable and favorable locations, respectively. After PS matching, 62 patients from group 1 and group 2 each were compared. Operative and postoperative course were similar in patients with HCC in favorable and unfavorable LLR locations. Surgical margins were found to be identical before and after PS. Conclusions: These results show that LLR in patients with HCC can be safely performed in all segments because of the extensive experience of all surgeons from multiple centers in performing traditional open liver surgery as well as laparoscopic surgery.

KW - Child B

KW - Hepatocellular carcinoma

KW - IGoMILS

KW - Laparoscopic HCC

KW - Laparoscopic liver resection

KW - Posterior segment

UR - http://www.scopus.com/inward/record.url?scp=85053025547&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053025547&partnerID=8YFLogxK

U2 - 10.1007/s00464-018-6426-3

DO - 10.1007/s00464-018-6426-3

M3 - Article

AN - SCOPUS:85053025547

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

ER -