Laparoscopic management of ovarian cysts in peripheral precocious puberty of McCune-Albright syndrome

Roberto Gesmundo, Riccardo Guanà, Laura Valfrè, Luisa De Sanctis, Patrizia Matarazzo, Daniela Marzari, Roberto Lala

Research output: Contribution to journalArticlepeer-review


Ovarian cysts are common in peripheral precocious puberty in McCune-Albright syndrome (MAS). The clinical course of these cysts is unpredictable due to episodes of hyper-estrogenism typical of MAS ovarian hyper-function. In persistent and recurrent large ovarian cysts with sustained estrogen hyper-secretion and relevant clinical disturbances (increased linear growth and bone age maturation, vaginal bleeding and psychological disturbances) treatment is mandatory. Experimental courses of estrogen-blocking drugs may have insufficient or nil therapeutic effects. In these cases and when molecular analysis is required to obtain MAS diagnosis as in isolated peripheral precocious puberty, surgery is the option. Laparoscopy minimizes surgical aggression and facilitates obtaining tissue samples for molecular analysis, and sometimes relieves hyperestrogenism with the excision of hyperactive ovarian areas. It can be conducted with trans-umbilical laparoscopic ovarian cystectomy (TULOC) before 3 years of age and with traditional techniques afterwards.

Original languageEnglish
Pages (from-to)571-575
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Issue numberSUPPL. 2
Publication statusPublished - 2006


  • Laparoscopy
  • McCune-Albright syndrome
  • Ovarian cysts

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health


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