Laparoscopic uterosacral ligament resection for dysmenorrhea associated with endometriosis: Results of a randomized, controlled trial

Paolo Vercellini, Giorgio Aimi, Mauro Busacca, Giovanni Apolone, Anna Uglietti, Pier Giorgio Crosignani

Research output: Contribution to journalArticle


Objective: To evaluate the efficacy of laparoscopic resection of the uterosacral ligaments in women with endometriosis and predominantly midline dysmenorrhea. Design: Randomized controlled trial. Setting: Two academic departments. Patient(s): One hundred eighty patients undergoing operative laparoscopy as first-line therapy for stage I to IV symptomatic endometriosis. Intervention(s): Operative laparoscopy including uterosacral ligament resection or conservative surgery alone. Main outcome measure(s): Proportion of women with recurrence of moderate or severe dysmenorrhea 1 year after surgery. Result(s): No complications occurred. Among the patients who were evaluable 1 year after operative laparoscopy, 23 of 78 (29%) women who had uterosacral ligament resection and 21 of 78 (27%) women who had conservative surgery only reported recurrent dysmenorrhea. The corresponding numbers of patients at 3 years were 21 of 59 (36%) women and 18 of 57 (32%) women, respectively. Time to recurrence was similar in the two groups. Pain was substantially reduced, and patients in both groups experienced similar and significant improvements in health-related quality of life, psychiatric profile, and sexual satisfaction. Overall, 68 of 90 (75%) patients in the uterosacral ligament resection group and 67 of 90 (74%) patients in the conservative surgery group were satisfied at 1 year. Conclusion(s): Addition of uterosacral ligament resection to conservative laparoscopic surgery for endometriosis did not reduce the medium- or long-term frequency and severity of recurrence of dysmenorrhea.

Original languageEnglish
Pages (from-to)310-319
Number of pages10
JournalFertility and Sterility
Issue number2
Publication statusPublished - Aug 1 2003



  • Conservative pelvic surgery
  • Deep dyspareunia
  • Dysmenorrhea
  • Endometriosis
  • Laparoscopy
  • Pelvic pain
  • Quality of life
  • Uterosacral ligaments

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this