Laparoscopic vs. open colectomy in cancer patients: Long-term complications, quality of life, and survival

Marco Braga, Matteo Frasson, Andrea Vignali, Walter Zuliani, Vittorio Civelli, Valerio Di Carlo

Research output: Contribution to journalArticlepeer-review


PURPOSE: This study was designed to evaluate long-term complications, quality of life, and survival rate in a series of colorectal cancer patients randomized to laparoscopic or open surgery. METHODS: A total of 391 patients with colorectal cancer were randomly assigned to laparoscopic (n = 190) or open (n = 201) resection. Long-term follow-up was performed every six months by office visits. Quality of life was assessed at 12, 24, and 48 months after surgery by a modified version of Short Form 36 Health Survey questionnaire. All patients were analyzed on an intention-to-treat basis. RESULTS: Eight (4.2 percent) laparoscopic group patients needed conversion to open surgery. Overall long-term morbidity rate was 6.8 percent (13/190) in the laparoscopic vs. 14.9 percent (30/201) in the open group (P = 0.018). Overall quality of life was significantly better in the laparoscopic group in the first 12 months after surgery, whereas at 24 months, patients of the laparoscopic group reported a significant advantage only in social functioning. No difference was found in both overall and disease-free survival rates by comparing laparoscopic vs. open group. CONCLUSIONS: Laparoscopic colorectal resection was associated with a lower incidence of long-term complications and a better quality of life in the first 12 months after surgery compared with open surgery. No difference between groups was found in overall and disease-free survival rates.

Original languageEnglish
Pages (from-to)2217-2223
Number of pages7
JournalDiseases of the Colon and Rectum
Issue number12
Publication statusPublished - Dec 2005


  • Colorectal cancer
  • Laparoscopy
  • Postoperative complications
  • Quality of life
  • Survival

ASJC Scopus subject areas

  • Gastroenterology


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