Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly: An age-stratified multicenter study on 1606 women

Stefano Uccella; Matteo Bonzini; Stefano Palomba; Francesco Fanfani; Mario Malzoni; Marcello Ceccaroni; Renato Seracchioli; Annamaria Ferrero; Roberto Berretta; Enrico Vizza; Davide Sturla; Giovanni Roviglione; Giorgia Monterossi; Paolo Casadio; Eugenio Volpi; Daniele Mautone; Giacomo Corrado; Francesco Bruni; Giovanni Scambia; Fabio Ghezzi

doi:10.1016/j.ygyno.2016.02.029

Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly: An age-stratified multicenter study on 1606 women

Stefano Uccella, Matteo Bonzini, Stefano Palomba, Francesco Fanfani, Mario Malzoni, Marcello Ceccaroni, Renato Seracchioli, Annamaria Ferrero, Roberto Berretta, Enrico Vizza, Davide Sturla, Giovanni Roviglione, Giorgia Monterossi, Paolo Casadio, Eugenio Volpi, Daniele Mautone, Giacomo Corrado, Francesco Bruni, Giovanni Scambia, Fabio Ghezzi

Research output: Contribution to journal › Article

Abstract

Objective. To investigate in depth the effect of increasing age on the peri-operative outcomes of laparoscopic treatment for endometrial cancer, compared to open surgery, with stratification of patients according to the different definitions of elderly age used in the literature. Methods: Data of consecutive patients who underwent surgery for endometrial cancer staging at six centers were reviewed and analyzed according to surgical approach (laparoscopic or open), different definitions of elderly and very elderly age (≥. 65. years, ≥. 75. years, ≥. 80. years), and class of age (. 0.05). The same tendency was observed among very-elderly patients (≥. 80. years). Multivariable and propensity score-matched analysis confirmed these findings. Conclusions: Laparoscopy for staging endometrial cancer retains its advantages over open surgery even in elderly and very-elderly patients. Our data strongly suggest that minimally-invasive surgery is advantageous even among subjects ≥. 80. years.

Original language	English
Journal	Gynecologic Oncology
DOIs	https://doi.org/10.1016/j.ygyno.2016.02.029
Publication status	Accepted/In press - Feb 5 2016

Keywords

Aging
Elderly
Endometrial cancer
Laparoscopy
Minimally-invasive
Surgery

ASJC Scopus subject areas

Obstetrics and Gynaecology
Oncology

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Uccella, S., Bonzini, M., Palomba, S., Fanfani, F., Malzoni, M., Ceccaroni, M., Seracchioli, R., Ferrero, A., Berretta, R., Vizza, E., Sturla, D., Roviglione, G., Monterossi, G., Casadio, P., Volpi, E., Mautone, D., Corrado, G., Bruni, F., Scambia, G., & Ghezzi, F. (Accepted/In press). Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly: An age-stratified multicenter study on 1606 women. Gynecologic Oncology. https://doi.org/10.1016/j.ygyno.2016.02.029

Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly : An age-stratified multicenter study on 1606 women. / Uccella, Stefano; Bonzini, Matteo; Palomba, Stefano; Fanfani, Francesco; Malzoni, Mario; Ceccaroni, Marcello; Seracchioli, Renato; Ferrero, Annamaria; Berretta, Roberto; Vizza, Enrico; Sturla, Davide; Roviglione, Giovanni; Monterossi, Giorgia; Casadio, Paolo; Volpi, Eugenio; Mautone, Daniele; Corrado, Giacomo; Bruni, Francesco; Scambia, Giovanni; Ghezzi, Fabio.

In: Gynecologic Oncology, 05.02.2016.

Research output: Contribution to journal › Article

Uccella, S, Bonzini, M, Palomba, S, Fanfani, F, Malzoni, M, Ceccaroni, M, Seracchioli, R, Ferrero, A, Berretta, R, Vizza, E, Sturla, D, Roviglione, G, Monterossi, G, Casadio, P, Volpi, E, Mautone, D, Corrado, G, Bruni, F, Scambia, G & Ghezzi, F 2016, 'Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly: An age-stratified multicenter study on 1606 women', Gynecologic Oncology. https://doi.org/10.1016/j.ygyno.2016.02.029

Uccella, Stefano ; Bonzini, Matteo ; Palomba, Stefano ; Fanfani, Francesco ; Malzoni, Mario ; Ceccaroni, Marcello ; Seracchioli, Renato ; Ferrero, Annamaria ; Berretta, Roberto ; Vizza, Enrico ; Sturla, Davide ; Roviglione, Giovanni ; Monterossi, Giorgia ; Casadio, Paolo ; Volpi, Eugenio ; Mautone, Daniele ; Corrado, Giacomo ; Bruni, Francesco ; Scambia, Giovanni ; Ghezzi, Fabio. / Laparoscopic vs. open treatment of endometrial cancer in the elderly and very elderly : An age-stratified multicenter study on 1606 women. In: Gynecologic Oncology. 2016.

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abstract = "Objective. To investigate in depth the effect of increasing age on the peri-operative outcomes of laparoscopic treatment for endometrial cancer, compared to open surgery, with stratification of patients according to the different definitions of elderly age used in the literature. Methods: Data of consecutive patients who underwent surgery for endometrial cancer staging at six centers were reviewed and analyzed according to surgical approach (laparoscopic or open), different definitions of elderly and very elderly age (≥. 65. years, ≥. 75. years, ≥. 80. years), and class of age (. 0.05). The same tendency was observed among very-elderly patients (≥. 80. years). Multivariable and propensity score-matched analysis confirmed these findings. Conclusions: Laparoscopy for staging endometrial cancer retains its advantages over open surgery even in elderly and very-elderly patients. Our data strongly suggest that minimally-invasive surgery is advantageous even among subjects ≥. 80. years.",

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AU - Fanfani, Francesco

AU - Malzoni, Mario

AU - Ceccaroni, Marcello

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AU - Sturla, Davide

AU - Roviglione, Giovanni

AU - Monterossi, Giorgia

AU - Casadio, Paolo

AU - Volpi, Eugenio

AU - Mautone, Daniele

AU - Corrado, Giacomo

AU - Bruni, Francesco

AU - Scambia, Giovanni

AU - Ghezzi, Fabio

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N2 - Objective. To investigate in depth the effect of increasing age on the peri-operative outcomes of laparoscopic treatment for endometrial cancer, compared to open surgery, with stratification of patients according to the different definitions of elderly age used in the literature. Methods: Data of consecutive patients who underwent surgery for endometrial cancer staging at six centers were reviewed and analyzed according to surgical approach (laparoscopic or open), different definitions of elderly and very elderly age (≥. 65. years, ≥. 75. years, ≥. 80. years), and class of age (. 0.05). The same tendency was observed among very-elderly patients (≥. 80. years). Multivariable and propensity score-matched analysis confirmed these findings. Conclusions: Laparoscopy for staging endometrial cancer retains its advantages over open surgery even in elderly and very-elderly patients. Our data strongly suggest that minimally-invasive surgery is advantageous even among subjects ≥. 80. years.

AB - Objective. To investigate in depth the effect of increasing age on the peri-operative outcomes of laparoscopic treatment for endometrial cancer, compared to open surgery, with stratification of patients according to the different definitions of elderly age used in the literature. Methods: Data of consecutive patients who underwent surgery for endometrial cancer staging at six centers were reviewed and analyzed according to surgical approach (laparoscopic or open), different definitions of elderly and very elderly age (≥. 65. years, ≥. 75. years, ≥. 80. years), and class of age (. 0.05). The same tendency was observed among very-elderly patients (≥. 80. years). Multivariable and propensity score-matched analysis confirmed these findings. Conclusions: Laparoscopy for staging endometrial cancer retains its advantages over open surgery even in elderly and very-elderly patients. Our data strongly suggest that minimally-invasive surgery is advantageous even among subjects ≥. 80. years.

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