Large-cell medulloblastoma with arrestin-like protein expression

S. Vincent, M. Mirshari, C. Nicolas, C. Adenis, P. Dhellemmes, G. Soto Ares, C. A. Maurage, M. C. Baranzelli, F. Giangaspero, M. M. Ruchoux

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report a case of a cerebellar large-cell medulloblastoma in a 12-year-old patient. Despite a gross-total resection followed by a radiation therapy and then a chemotherapy, the death occurred 6 months later. The cyogenetic analysis showed an isochromosome 17q. Immunoreactivity for synaptophysin, neurofilaments, chromogranin and arrestin-like proteins was detected, whereas rhodopsin, vimentin, EMA and PAX-6 were negative. In this study, we demonstrate that large-cell medulloblastoma with translocation in chromosome 17q is a neuronal differentiated medulloblastoma with non-photoreceptor characterization. By reverse transcription and polymerase chain reaction (RT-PCR) method, using primers for β1, β2 and visual arrestin, we demonstrate corresponding mRNA for β1, β2 arrestin but not for visual arrestin. These results suggest that arrestin immunoreactivity in this tumor corresponds to non-visual arrestin. This case corresponds to a new entity of large-cell medulloblastoma. The potential role of a new marker linked to a β2 adrenergic receptor needs further molecular characterization to be useful.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalClinical Neuropathology
Volume22
Issue number1
Publication statusPublished - Jan 2003

Fingerprint

Arrestin
Medulloblastoma
Proteins
Isochromosomes
Chromogranins
Synaptophysin
Rhodopsin
Intermediate Filaments
Vimentin
Adrenergic Receptors
Reverse Transcription
Radiotherapy
Chromosomes
Drug Therapy
Polymerase Chain Reaction
Messenger RNA
Neoplasms
beta-Arrestin 1

Keywords

  • β arrestin
  • Cytogenetic
  • Large-cell medulloblastoma
  • Neuronal differentiation

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Vincent, S., Mirshari, M., Nicolas, C., Adenis, C., Dhellemmes, P., Ares, G. S., ... Ruchoux, M. M. (2003). Large-cell medulloblastoma with arrestin-like protein expression. Clinical Neuropathology, 22(1), 1-9.

Large-cell medulloblastoma with arrestin-like protein expression. / Vincent, S.; Mirshari, M.; Nicolas, C.; Adenis, C.; Dhellemmes, P.; Ares, G. Soto; Maurage, C. A.; Baranzelli, M. C.; Giangaspero, F.; Ruchoux, M. M.

In: Clinical Neuropathology, Vol. 22, No. 1, 01.2003, p. 1-9.

Research output: Contribution to journalArticle

Vincent, S, Mirshari, M, Nicolas, C, Adenis, C, Dhellemmes, P, Ares, GS, Maurage, CA, Baranzelli, MC, Giangaspero, F & Ruchoux, MM 2003, 'Large-cell medulloblastoma with arrestin-like protein expression', Clinical Neuropathology, vol. 22, no. 1, pp. 1-9.
Vincent S, Mirshari M, Nicolas C, Adenis C, Dhellemmes P, Ares GS et al. Large-cell medulloblastoma with arrestin-like protein expression. Clinical Neuropathology. 2003 Jan;22(1):1-9.
Vincent, S. ; Mirshari, M. ; Nicolas, C. ; Adenis, C. ; Dhellemmes, P. ; Ares, G. Soto ; Maurage, C. A. ; Baranzelli, M. C. ; Giangaspero, F. ; Ruchoux, M. M. / Large-cell medulloblastoma with arrestin-like protein expression. In: Clinical Neuropathology. 2003 ; Vol. 22, No. 1. pp. 1-9.
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