Large granular lymphocyte leukemia associated with hepatocellular carcinoma: A case report

Giacomo Borgonovo, Vincenzo Secondo, Emanuela Varaldo, Vito Pistoia, Marco Gobbi, Francesco Paolo Mattioli

Research output: Contribution to journalArticlepeer-review


The association of large granular lymphocyte leukemia (LGL-L) with hepatocellular carcinoma in a 55-year-old patient is described. An increased number of LGL was seen on peripheral blood smears. The immunophenotype was CD3+, CD4-, CD8+, and a study of the TCR gene rearrangement indicated the monoclonal nature of the proliferation. A liver mass was detected on CT scan and an ultrasound-guided fine needle biopsy revealed the presence of hepatocholangiocellular elements. A right hepatectomy was performed. Major neutropenia persisted despite corticosteroids and granulocyte colony-stimulating growth factor (G-CSF) therapy. Methotrexate at 20 mg/week failed to control lymphocytosis after three months of treatment. A new nodule of hepatocarcinoma reappeared twelve months after surgery and a liver resection was performed.

Original languageEnglish
Pages (from-to)172-174
Number of pages3
Issue number2
Publication statusPublished - Mar 1996


  • Hepatectomy
  • Hepatoma
  • Large granular lymphocyte
  • Leukemia
  • Neutropenia
  • T-lymphocytes

ASJC Scopus subject areas

  • Hematology


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