Large liver cell dysplasia

A controversial entity

Young Nyun Park, Massimo Roncalli

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Large cell change (LCC) is a noncommittal term used today to indicate liver cell dysplasia of the large cell type. Dysplasia was deleted from the original definition because not enough evidence has been collected over time to support premalignancy. LCC is a microscopically well-defined lesion, usually found in cirrhosis, whose origin, natural history, and fate are still debated. Different morphologic, phenotypic, molecular and clinical studies have been performed to address the issue of the dysplastic versus reactive nature of this lesion. The aim of this review is to critically evaluate the contributions to the topic and to underline that the heterogeneity of the lesion is an important issue to be taken into account for our biological understanding of it. While LCC has important morphologic analogies in experimental liver carcinogenesis, no comparable lesions are known in solid non-liver parenchymal human tissues that morphologically feature dysplasia, but in which it is uncertain whether the lesions are reactive or preneoplastic. The debate over the lesion may be useful in learning the actual limits of morphology and how additional information can be gained by looking inside the cells.

Original languageEnglish
Pages (from-to)734-743
Number of pages10
JournalJournal of Hepatology
Volume45
Issue number5
DOIs
Publication statusPublished - Nov 2006

Fingerprint

Liver
Natural History
Carcinogenesis
Fibrosis
Learning

Keywords

  • Cirrhosis
  • Hepatocellular carcinoma
  • Large liver cell change
  • Large liver cell dysplasia

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Large liver cell dysplasia : A controversial entity. / Park, Young Nyun; Roncalli, Massimo.

In: Journal of Hepatology, Vol. 45, No. 5, 11.2006, p. 734-743.

Research output: Contribution to journalArticle

Park, Young Nyun ; Roncalli, Massimo. / Large liver cell dysplasia : A controversial entity. In: Journal of Hepatology. 2006 ; Vol. 45, No. 5. pp. 734-743.
@article{9b1e2e8715024991b6639d217363e90b,
title = "Large liver cell dysplasia: A controversial entity",
abstract = "Large cell change (LCC) is a noncommittal term used today to indicate liver cell dysplasia of the large cell type. Dysplasia was deleted from the original definition because not enough evidence has been collected over time to support premalignancy. LCC is a microscopically well-defined lesion, usually found in cirrhosis, whose origin, natural history, and fate are still debated. Different morphologic, phenotypic, molecular and clinical studies have been performed to address the issue of the dysplastic versus reactive nature of this lesion. The aim of this review is to critically evaluate the contributions to the topic and to underline that the heterogeneity of the lesion is an important issue to be taken into account for our biological understanding of it. While LCC has important morphologic analogies in experimental liver carcinogenesis, no comparable lesions are known in solid non-liver parenchymal human tissues that morphologically feature dysplasia, but in which it is uncertain whether the lesions are reactive or preneoplastic. The debate over the lesion may be useful in learning the actual limits of morphology and how additional information can be gained by looking inside the cells.",
keywords = "Cirrhosis, Hepatocellular carcinoma, Large liver cell change, Large liver cell dysplasia",
author = "Park, {Young Nyun} and Massimo Roncalli",
year = "2006",
month = "11",
doi = "10.1016/j.jhep.2006.08.002",
language = "English",
volume = "45",
pages = "734--743",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier B.V.",
number = "5",

}

TY - JOUR

T1 - Large liver cell dysplasia

T2 - A controversial entity

AU - Park, Young Nyun

AU - Roncalli, Massimo

PY - 2006/11

Y1 - 2006/11

N2 - Large cell change (LCC) is a noncommittal term used today to indicate liver cell dysplasia of the large cell type. Dysplasia was deleted from the original definition because not enough evidence has been collected over time to support premalignancy. LCC is a microscopically well-defined lesion, usually found in cirrhosis, whose origin, natural history, and fate are still debated. Different morphologic, phenotypic, molecular and clinical studies have been performed to address the issue of the dysplastic versus reactive nature of this lesion. The aim of this review is to critically evaluate the contributions to the topic and to underline that the heterogeneity of the lesion is an important issue to be taken into account for our biological understanding of it. While LCC has important morphologic analogies in experimental liver carcinogenesis, no comparable lesions are known in solid non-liver parenchymal human tissues that morphologically feature dysplasia, but in which it is uncertain whether the lesions are reactive or preneoplastic. The debate over the lesion may be useful in learning the actual limits of morphology and how additional information can be gained by looking inside the cells.

AB - Large cell change (LCC) is a noncommittal term used today to indicate liver cell dysplasia of the large cell type. Dysplasia was deleted from the original definition because not enough evidence has been collected over time to support premalignancy. LCC is a microscopically well-defined lesion, usually found in cirrhosis, whose origin, natural history, and fate are still debated. Different morphologic, phenotypic, molecular and clinical studies have been performed to address the issue of the dysplastic versus reactive nature of this lesion. The aim of this review is to critically evaluate the contributions to the topic and to underline that the heterogeneity of the lesion is an important issue to be taken into account for our biological understanding of it. While LCC has important morphologic analogies in experimental liver carcinogenesis, no comparable lesions are known in solid non-liver parenchymal human tissues that morphologically feature dysplasia, but in which it is uncertain whether the lesions are reactive or preneoplastic. The debate over the lesion may be useful in learning the actual limits of morphology and how additional information can be gained by looking inside the cells.

KW - Cirrhosis

KW - Hepatocellular carcinoma

KW - Large liver cell change

KW - Large liver cell dysplasia

UR - http://www.scopus.com/inward/record.url?scp=33749067406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749067406&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2006.08.002

DO - 10.1016/j.jhep.2006.08.002

M3 - Article

VL - 45

SP - 734

EP - 743

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 5

ER -