Abstract
PURPOSE: To evaluate whether coagulation necrosis achievable with radio- frequency (RF) ablation can be increased by using a cluster of closely spaced electrodes. MATERIALS AND METHODS: RF was applied to ex vivo liver (n = 68), in vivo liver (n = 12), and in vivo muscle (n = 15) by using a cluster array of three separate internally cooled electrodes spaced 0.5 cm apart. The diameter of coagulation necrosis achieved with optimal RF deposition (1,400- 2,150 peak mA) for 5-60 minutes of RF application was determined for electrode tip lengths of 1.5-3.0 cm and compared with that obtained by using a single electrode and otherwise similar technique. Ten patients with solitary intrahepatic colorectal metastases were also treated by using cluster electrode RF ablation. RESULTS: In ex vivo liver, simultaneous RF application to electrode clusters for 15, 30, and 45 minutes produced 4.7 cm ± 0.1, 6.2 cm ± 0.1, and 7.0 cm ± 0.2 of coagulation necrosis, respectively. In in vivo liver and muscle, RF applied to electrode clusters for 12 minutes yielded 3.1 cm ± 0.2 and 7.6 cm ± 0.4 of coagulation, respectively. RF application to a single electrode produced maximal coagulation of 2.9 cm in ex vivo liver, 1.8 cm in in vivo liver, and 4.3 cm in muscle (P <.01, all tissues). In colorectal metastases, a single 12-15- minute application of RF to an electrode cluster induced 4.5-7.0 cm of coagulation necrosis. CONCLUSION: Simultaneous RF application to a cluster of three closely spaced internally cooled electrodes enables a larger volume of coagulation in ex vivo liver, in vivo tissues, and hepatic colorectal metastases than previously reported.
| Original language | English |
|---|---|
| Pages (from-to) | 371-379 |
| Number of pages | 9 |
| Journal | Radiology |
| Volume | 209 |
| Issue number | 2 |
| Publication status | Published - Nov 1998 |
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Keywords
- Liver neoplasms
- Liver neoplasms, therapy
- Radiofrequency (RF) ablation
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Large-volume tissue ablation with radio frequency by using a clustered, internally cooled electrode technique : Laboratory and clinical experience in liver metastases. / Goldberg, S. Nahum; Solbiati, Luigi; Hahn, Peter F.; Cosman, Eric; Conrad, Jennifer E.; Fogle, Robert; Gazelle, G. Scott.
In: Radiology, Vol. 209, No. 2, 11.1998, p. 371-379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Large-volume tissue ablation with radio frequency by using a clustered, internally cooled electrode technique
T2 - Laboratory and clinical experience in liver metastases
AU - Goldberg, S. Nahum
AU - Solbiati, Luigi
AU - Hahn, Peter F.
AU - Cosman, Eric
AU - Conrad, Jennifer E.
AU - Fogle, Robert
AU - Gazelle, G. Scott
PY - 1998/11
Y1 - 1998/11
N2 - PURPOSE: To evaluate whether coagulation necrosis achievable with radio- frequency (RF) ablation can be increased by using a cluster of closely spaced electrodes. MATERIALS AND METHODS: RF was applied to ex vivo liver (n = 68), in vivo liver (n = 12), and in vivo muscle (n = 15) by using a cluster array of three separate internally cooled electrodes spaced 0.5 cm apart. The diameter of coagulation necrosis achieved with optimal RF deposition (1,400- 2,150 peak mA) for 5-60 minutes of RF application was determined for electrode tip lengths of 1.5-3.0 cm and compared with that obtained by using a single electrode and otherwise similar technique. Ten patients with solitary intrahepatic colorectal metastases were also treated by using cluster electrode RF ablation. RESULTS: In ex vivo liver, simultaneous RF application to electrode clusters for 15, 30, and 45 minutes produced 4.7 cm ± 0.1, 6.2 cm ± 0.1, and 7.0 cm ± 0.2 of coagulation necrosis, respectively. In in vivo liver and muscle, RF applied to electrode clusters for 12 minutes yielded 3.1 cm ± 0.2 and 7.6 cm ± 0.4 of coagulation, respectively. RF application to a single electrode produced maximal coagulation of 2.9 cm in ex vivo liver, 1.8 cm in in vivo liver, and 4.3 cm in muscle (P <.01, all tissues). In colorectal metastases, a single 12-15- minute application of RF to an electrode cluster induced 4.5-7.0 cm of coagulation necrosis. CONCLUSION: Simultaneous RF application to a cluster of three closely spaced internally cooled electrodes enables a larger volume of coagulation in ex vivo liver, in vivo tissues, and hepatic colorectal metastases than previously reported.
AB - PURPOSE: To evaluate whether coagulation necrosis achievable with radio- frequency (RF) ablation can be increased by using a cluster of closely spaced electrodes. MATERIALS AND METHODS: RF was applied to ex vivo liver (n = 68), in vivo liver (n = 12), and in vivo muscle (n = 15) by using a cluster array of three separate internally cooled electrodes spaced 0.5 cm apart. The diameter of coagulation necrosis achieved with optimal RF deposition (1,400- 2,150 peak mA) for 5-60 minutes of RF application was determined for electrode tip lengths of 1.5-3.0 cm and compared with that obtained by using a single electrode and otherwise similar technique. Ten patients with solitary intrahepatic colorectal metastases were also treated by using cluster electrode RF ablation. RESULTS: In ex vivo liver, simultaneous RF application to electrode clusters for 15, 30, and 45 minutes produced 4.7 cm ± 0.1, 6.2 cm ± 0.1, and 7.0 cm ± 0.2 of coagulation necrosis, respectively. In in vivo liver and muscle, RF applied to electrode clusters for 12 minutes yielded 3.1 cm ± 0.2 and 7.6 cm ± 0.4 of coagulation, respectively. RF application to a single electrode produced maximal coagulation of 2.9 cm in ex vivo liver, 1.8 cm in in vivo liver, and 4.3 cm in muscle (P <.01, all tissues). In colorectal metastases, a single 12-15- minute application of RF to an electrode cluster induced 4.5-7.0 cm of coagulation necrosis. CONCLUSION: Simultaneous RF application to a cluster of three closely spaced internally cooled electrodes enables a larger volume of coagulation in ex vivo liver, in vivo tissues, and hepatic colorectal metastases than previously reported.
KW - Liver neoplasms
KW - Liver neoplasms, therapy
KW - Radiofrequency (RF) ablation
UR - http://www.scopus.com/inward/record.url?scp=0000097040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0000097040&partnerID=8YFLogxK
M3 - Article
C2 - 9807561
AN - SCOPUS:0000097040
VL - 209
SP - 371
EP - 379
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 2
ER -