TY - JOUR
T1 - Laryngeal dysplasia
T2 - Oncological outcomes in a large cohort of patients treated in a tertiary comprehensive cancer centre
AU - Chu, Francesco
AU - De Santi, Silvia
AU - Tagliabue, Marta
AU - De Benedetto, Luigi
AU - Zorzi, Stefano
AU - Pietrobon, Giacomo
AU - Herman, Irene
AU - Maffini, Fausto
AU - Chiocca, Susanna
AU - Corso, Federica
AU - Gandini, Sara
AU - Ansarin, Mohssen
N1 - Funding Information:
This work was partially supported by the Ministry of Health, Italy with Ricerca Corrente and 5 × 1000 funds.
Publisher Copyright:
© 2021 Elsevier Inc.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/3/1
Y1 - 2021/3/1
N2 - Purpose: Laryngeal dysplasia represents a series of precancerous lesions, observed as laryngeal leukoplakia. General agreement has been lacking for their management and treatment ranging from simple biopsy to complete excision with cold blade/laser. In this work, we aim at providing the oncological outcomes of patients affected by laryngeal dysplasia, treated with a single modality, and at identifying clinical parameters predictive of malignant transformation. Materials and methods: We performed a retrospective analysis of patients treated with transoral laser microsurgery between January 2005 and December 2015 in a tertiary comprehensive cancer centre. Data were collected about smoke and alcohol habits, site of the laryngeal lesion, surgical outcomes and progression to invasive squamous cell carcinoma. Results: The grade of dysplasia, margins' status and smoke habit were not associated with a significantly worse DFS and a higher risk of invasive SCC. We identified three parameters (supraglottic involvement, multifocality and history of more than one recurrence of dysplasia) that have a significant prognostic value. Conclusions: On the base of these clinical parameters, a more intensive follow-up might be warranted for high-risk patients.
AB - Purpose: Laryngeal dysplasia represents a series of precancerous lesions, observed as laryngeal leukoplakia. General agreement has been lacking for their management and treatment ranging from simple biopsy to complete excision with cold blade/laser. In this work, we aim at providing the oncological outcomes of patients affected by laryngeal dysplasia, treated with a single modality, and at identifying clinical parameters predictive of malignant transformation. Materials and methods: We performed a retrospective analysis of patients treated with transoral laser microsurgery between January 2005 and December 2015 in a tertiary comprehensive cancer centre. Data were collected about smoke and alcohol habits, site of the laryngeal lesion, surgical outcomes and progression to invasive squamous cell carcinoma. Results: The grade of dysplasia, margins' status and smoke habit were not associated with a significantly worse DFS and a higher risk of invasive SCC. We identified three parameters (supraglottic involvement, multifocality and history of more than one recurrence of dysplasia) that have a significant prognostic value. Conclusions: On the base of these clinical parameters, a more intensive follow-up might be warranted for high-risk patients.
KW - Laryngeal cancer
KW - Laryngeal dysplasia
KW - Precancerous lesion
KW - Transoral laser microsurgery
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U2 - 10.1016/j.amjoto.2020.102861
DO - 10.1016/j.amjoto.2020.102861
M3 - Article
AN - SCOPUS:85099215451
VL - 42
JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery
SN - 0196-0709
IS - 2
M1 - 102861
ER -