Laryngeal dysplasia: Oncological outcomes in a large cohort of patients treated in a tertiary comprehensive cancer centre

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PURPOSE: Laryngeal dysplasia represents a series of precancerous lesions, observed as laryngeal leukoplakia. General agreement has been lacking for their management and treatment ranging from simple biopsy to complete excision with cold blade/laser. In this work, we aim at providing the oncological outcomes of patients affected by laryngeal dysplasia, treated with a single modality, and at identifying clinical parameters predictive of malignant transformation.

MATERIALS AND METHODS: We performed a retrospective analysis of patients treated with transoral laser microsurgery between January 2005 and December 2015 in a tertiary comprehensive cancer centre. Data were collected about smoke and alcohol habits, site of the laryngeal lesion, surgical outcomes and progression to invasive squamous cell carcinoma.

RESULTS: The grade of dysplasia, margins' status and smoke habit were not associated with a significantly worse DFS and a higher risk of invasive SCC. We identified three parameters (supraglottic involvement, multifocality and history of more than one recurrence of dysplasia) that have a significant prognostic value.

CONCLUSIONS: On the base of these clinical parameters, a more intensive follow-up might be warranted for high-risk patients.

Original languageEnglish
Pages (from-to)102861
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Issue number2
Publication statusPublished - Jan 15 2021


  • Cancer Care Facilities/statistics & numerical data
  • Carcinoma, Squamous Cell/epidemiology
  • Cell Transformation, Neoplastic
  • Disease Progression
  • Female
  • Humans
  • Laryngeal Neoplasms/epidemiology
  • Male
  • Odds Ratio
  • Precancerous Conditions
  • Retrospective Studies
  • Risk
  • Smoking/adverse effects
  • Tertiary Care Centers/statistics & numerical data
  • Treatment Outcome


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