PURPOSE: Laryngeal dysplasia represents a series of precancerous lesions, observed as laryngeal leukoplakia. General agreement has been lacking for their management and treatment ranging from simple biopsy to complete excision with cold blade/laser. In this work, we aim at providing the oncological outcomes of patients affected by laryngeal dysplasia, treated with a single modality, and at identifying clinical parameters predictive of malignant transformation.
MATERIALS AND METHODS: We performed a retrospective analysis of patients treated with transoral laser microsurgery between January 2005 and December 2015 in a tertiary comprehensive cancer centre. Data were collected about smoke and alcohol habits, site of the laryngeal lesion, surgical outcomes and progression to invasive squamous cell carcinoma.
RESULTS: The grade of dysplasia, margins' status and smoke habit were not associated with a significantly worse DFS and a higher risk of invasive SCC. We identified three parameters (supraglottic involvement, multifocality and history of more than one recurrence of dysplasia) that have a significant prognostic value.
CONCLUSIONS: On the base of these clinical parameters, a more intensive follow-up might be warranted for high-risk patients.
|Journal||American Journal of Otolaryngology - Head and Neck Medicine and Surgery|
|Publication status||Published - Jan 15 2021|
- Cancer Care Facilities/statistics & numerical data
- Carcinoma, Squamous Cell/epidemiology
- Cell Transformation, Neoplastic
- Disease Progression
- Laryngeal Neoplasms/epidemiology
- Odds Ratio
- Precancerous Conditions
- Retrospective Studies
- Smoking/adverse effects
- Tertiary Care Centers/statistics & numerical data
- Treatment Outcome