Laser-Evoked Potentials to Pudendal Stimulation in Healthy Subjects: A Pilot Study

Emma Frasson, Maria Chiara Tozzi, Monia Bordignon, Luisa Motti, Francesca Ferrari, Gabriella Torre, Alessandra Graziottin, Salvatore Monaco, Laura Bertolasi

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: Laser-evoked potentials (LEPs) are useful neurophysiological tools for investigating the A-delta sensory peripheral fibers and the central nociceptive pathway. The current investigation aims to obtain normative values of LEPs via pudendal nerve stimulation in healthy adult volunteers. METHODS: Laser-evoked potentials were recorded in 16 men and 22 women, 22 to 75 years of age, using neodymium and yttrium and aluminum and perovskite laser bilateral stimulation to the pudendal nerve-supplied skin and the dorsal surface of the hands and feet. We assessed the perceptive threshold, latency, and amplitude of the N1 component and main vertex N2-P2 complex. The relationship between gender, age, height, and site of stimulation was statistically analyzed. RESULTS: Both in men and in women, laser perceptive threshold increased from genitalia to foot and from hand to foot (P ≤ 0.001). N1 and N2-P2 latencies progressively increased from pudendal area to hand to foot (P ≤ 0.008). N1 and N2-P2 complex LEP amplitudes progressively decreased from hand to genitalia to foot (P ≤ 0.04). The latencies of N1 component and N2-P2 complex of LEPs correlated with body height, whereas the amplitude of the N2-P2 complex correlated negatively with age; no correlations were observed between the latencies and amplitudes with gender. CONCLUSIONS: This study provides normative data on pudendal LEPs versus hand and foot LEPs. Incorporation of pudendal LEPs into clinical practice could provide a valuable neurophysiological tool for the study of pelvic pain syndromes.
Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalJournal of clinical neurophysiology : official publication of the American Electroencephalographic Society
Volume38
Issue number4
DOIs
Publication statusPublished - Jul 1 2021

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