Laser photocoagulation as treatment of non-exudative age-related macular degeneration: state-of-the-art and future perspectives

G Querques, MV Cicinelli, A Rabiolo, L de Vitis, R Sacconi, L Querques, F Bandello

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To give an updated review of laser approaches to non-exudative age-related macular degeneration (AMD). Methods: PubMed and Medline database searches were carried out using the terms “laser” and “photocoagulation” associated with “age-related macular degeneration”, and latest publications up to May 2017 have been reviewed. Moreover, the design of an ongoing single-center, non-randomized, phase I–II, pilot study, the PASCAL-GA trial, coordinated by F. Bandello, MD and G. Querques, MD from the IRCCS Ospedale San Raffaele, is described. Results: Either standard or subthreshold laser strategies have been tried to induce regression of distinct phenotypes of AMD, as reticular pseudodrusen (RPD), nascent geographic atrophy (nGA), and drusen-associated geographic atrophy (DAGA), with heterogeneous results. The aim of the PASCAL-GA protocol is to assess if subthreshold laser can restore the retinal pigment epithelium function in eyes with RPD and nGA offering a protective effect against extensive GA. Conclusions: New-generation medical and surgical approaches, including subthreshold laser photocoagulation, may have some success in downstaging AMD. © 2017 Springer-Verlag GmbH Germany, part of Springer Nature
Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume256
Issue number1
DOIs
Publication statusPublished - 2018

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