Laser scanning in vivo confocal microscopy in a case of terrien marginal degeneration

Giulio Ferrari, Salvatore Tedesco, Elisabetta Delfini, Claudio MacAluso

Research output: Contribution to journalArticlepeer-review


Purpose: To describe corneal microstructural modifications in an early case of Terrien marginal degeneration by means of laser scanning in vivo corneal confocal microscopy. Methods: A 20-year-old man affected by Terrien marginal degeneration in his right eye was examined with the Heidelberg Retina Tomograph 2 with a Rostock Cornea Module. The patient presented a corneal lesion with marked superior thinning and no clinical signs of inflammation. The left eye showed no clinical signs of degeneration. Results: The right eye showed irregular Bowman's membrane, amorphous-appearing substance colocalizing with lipid exudation, and needle-like hyperreflective material in the affected peripheral corneal region. Abnormally scarce and branched sub-basal plexus nerves as well as numerous activated keratocytes, sometimes organized in hyperreflective nests, were observed in the central cornea of the same eye. Although the left eyewas clinically unaffected, activated keratocytes were detected in its anterior central stroma. Conclusions: In vivo confocal microscopy supports the hypothesis of a mild inflammatory state with an atypical sub-basal nerve pattern in a patient affected by Terrien marginal degeneration. This new technique shows promise in studying this still elusive pathology.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
Issue number4
Publication statusPublished - Apr 2010


  • corneal nerves
  • histopathology
  • in vivo confocal microscopy
  • terrien disease

ASJC Scopus subject areas

  • Ophthalmology


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