Laser stimulation on bone defect healing

An in vitro study

G. A. Guzzardella, M. Fini, P. Torricelli, G. Giavaresi, R. Giardino

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

The aim of this in vitro study was to evaluate whether low-power laser (LPL) stimulation can accelerate bone healing. Bone defects of a standard area were created in the distal epiphysis of 12 femora explanted from six rats, and they were cultured in BGJb medium for 21 days. Six defects were treated daily with Ga-Al-As, 780 nm LPL for 10 consecutive days (lased group, LG), while the remainder were sham-treated (control group, CG). Alkaline phosphatase/total protein (ALP/TP), calcium (Ca), and nitric oxide (NO) were tested on days 7, 14 and 21 to monitor the metabolism of cultured bone. The percentage of healing of the defect area was determined by histomorphometric analysis. After 21 days significant increases were observed in ALP/TP in LG versus CG (p

Original languageEnglish
Pages (from-to)216-220
Number of pages5
JournalLasers in Medical Science
Volume17
Issue number3
DOIs
Publication statusPublished - 2002

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Lasers
Bone and Bones
Alkaline Phosphatase
Control Groups
Epiphyses
Femur
Nitric Oxide
Proteins
In Vitro Techniques
lime

Keywords

  • Bone healing
  • Experiment
  • Low-power laser
  • Organ culture

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Surgery

Cite this

Laser stimulation on bone defect healing : An in vitro study. / Guzzardella, G. A.; Fini, M.; Torricelli, P.; Giavaresi, G.; Giardino, R.

In: Lasers in Medical Science, Vol. 17, No. 3, 2002, p. 216-220.

Research output: Contribution to journalArticle

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