Laser synthesized nanoparticles for therapeutic drug monitoring

Matteo Tommasini, Chiara Zanchi, Andrea Lucotti, Enza Fazio, Marco Santoro, Salvatore Spadaro, Fortunato Neri, Sebastiano Trusso, Emilio Ciusani, Ugo de Grazia, Marina Casazza, Paolo M. Ossi

Research output: Chapter in Book/Report/Conference proceedingChapter


In this chapter are illustrated the context and activities that have been pursued to develop a surface enhanced Raman spectroscopy technique for clinical applications in therapeutic drug monitoring with focus on anti-epileptic and anti-Parkinson drugs. We discuss how the surface nanostructure of sensors made of arrays of noble metal nanoparticle obtained by pulsed laser ablation in inert gas and in liquid affects their optical properties, in particular the wavelength, intensity and width of the surface plasmon. These in turn are shown to strongly influence the intensity and the spatial reproducibility of the enhanced Raman signals as functions of drug concentration.

Original languageEnglish
Title of host publicationSpringer Series in Materials Science
PublisherSpringer Verlag
Number of pages22
Publication statusPublished - Jan 1 2018

Publication series

NameSpringer Series in Materials Science
ISSN (Print)0933-033X

ASJC Scopus subject areas

  • Materials Science(all)


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