Laser synthesized nanoparticles for therapeutic drug monitoring

Matteo Tommasini; Chiara Zanchi; Andrea Lucotti; Enza Fazio; Marco Santoro; Salvatore Spadaro; Fortunato Neri; Sebastiano Trusso; Emilio Ciusani; Ugo de Grazia; Marina Casazza; Paolo M. Ossi

doi:10.1007/978-3-319-96845-2_12

Laser synthesized nanoparticles for therapeutic drug monitoring

Matteo Tommasini, Chiara Zanchi, Andrea Lucotti, Enza Fazio, Marco Santoro, Salvatore Spadaro, Fortunato Neri, Sebastiano Trusso, Emilio Ciusani, Ugo de Grazia, Marina Casazza, Paolo M. Ossi

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

In this chapter are illustrated the context and activities that have been pursued to develop a surface enhanced Raman spectroscopy technique for clinical applications in therapeutic drug monitoring with focus on anti-epileptic and anti-Parkinson drugs. We discuss how the surface nanostructure of sensors made of arrays of noble metal nanoparticle obtained by pulsed laser ablation in inert gas and in liquid affects their optical properties, in particular the wavelength, intensity and width of the surface plasmon. These in turn are shown to strongly influence the intensity and the spatial reproducibility of the enhanced Raman signals as functions of drug concentration.

Original language	English
Title of host publication	Springer Series in Materials Science
Publisher	Springer Verlag
Pages	339-360
Number of pages	22
DOIs	https://doi.org/10.1007/978-3-319-96845-2_12
Publication status	Published - Jan 1 2018

Publication series

Name	Springer Series in Materials Science
Volume	274
ISSN (Print)	0933-033X

ASJC Scopus subject areas

Materials Science(all)

Access to Document

10.1007/978-3-319-96845-2_12

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Tommasini, M., Zanchi, C., Lucotti, A., Fazio, E., Santoro, M., Spadaro, S., Neri, F., Trusso, S., Ciusani, E., de Grazia, U., Casazza, M., & Ossi, P. M. (2018). Laser synthesized nanoparticles for therapeutic drug monitoring. In Springer Series in Materials Science (pp. 339-360). (Springer Series in Materials Science; Vol. 274). Springer Verlag. https://doi.org/10.1007/978-3-319-96845-2_12

Laser synthesized nanoparticles for therapeutic drug monitoring. / Tommasini, Matteo; Zanchi, Chiara; Lucotti, Andrea; Fazio, Enza; Santoro, Marco; Spadaro, Salvatore; Neri, Fortunato; Trusso, Sebastiano; Ciusani, Emilio ; de Grazia, Ugo ; Casazza, Marina; Ossi, Paolo M.

Springer Series in Materials Science. Springer Verlag, 2018. p. 339-360 (Springer Series in Materials Science; Vol. 274).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Tommasini, M, Zanchi, C, Lucotti, A, Fazio, E, Santoro, M, Spadaro, S, Neri, F, Trusso, S, Ciusani, E , de Grazia, U , Casazza, M & Ossi, PM 2018, Laser synthesized nanoparticles for therapeutic drug monitoring. in Springer Series in Materials Science. Springer Series in Materials Science, vol. 274, Springer Verlag, pp. 339-360. https://doi.org/10.1007/978-3-319-96845-2_12

Tommasini, Matteo ; Zanchi, Chiara ; Lucotti, Andrea ; Fazio, Enza ; Santoro, Marco ; Spadaro, Salvatore ; Neri, Fortunato ; Trusso, Sebastiano ; Ciusani, Emilio ; de Grazia, Ugo ; Casazza, Marina ; Ossi, Paolo M. / Laser synthesized nanoparticles for therapeutic drug monitoring. Springer Series in Materials Science. Springer Verlag, 2018. pp. 339-360 (Springer Series in Materials Science).

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