Laser technology in orthopedics: Preliminary study on low power laser therapy to improve the bone-biomaterial interface

Gaetano Antonio Guzzardella, P. Torricelli, N. Nicoli Aldini, R. Giardino

Research output: Contribution to journalArticle


Low Power Laser (LPL) seems to enhance the healing of bone defects and fractures. The effect of LPL in other orthopedic areas such as osteointegration of implanted prosthetic bone devices is still unclear. In the present study, 12 rabbits were used to evaluate whether Ga-Al-As (780 nm) LPL stimulation has positive effects on osteointegration. Hydroxyapatite (HA) cylindrical nails were drilled into both distal femurs of rabbits. From postoperative day 1 and for 5 consecutive days, the left femura of all rabbits were given LPL treatment (Laser Group-LG) with the following parameters: 300 Joule/cm2, 1 Watt, 300 Hertz, pulsating emission, 10 minutes. The right femura were sham-treated (Control Group-CG). At 4 and 8 weeks after implantation, histologic and histomorphometric investigations evaluated bone-biomaterial-contact. Histomorphometry showed a higher degree of osteointegration at the HA-bone interface in the LG Group at 4 (p

Original languageEnglish
Pages (from-to)898-902
Number of pages5
JournalInternational Journal of Artificial Organs
Issue number12
Publication statusPublished - 2001



  • Biomaterial
  • Bone-biomaterial interface
  • Diode laser
  • Low-power laser

ASJC Scopus subject areas

  • Biophysics

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