Laser writing of nanostructured silicon arrays for the SERS detection of biomolecules with inhibited oxidation

P. Pellacani, V. Torres-Costa, F. Agulló-Rueda, R. Vanna, C. Morasso, M. Manso Silván

Research output: Contribution to journalArticle

Abstract

The present work reports the processing of laser irradiated Si arrays (LISi) and underlines their surface enhanced Raman scattering (SERS) functionality. A nanostructured Si/SiOx surface forms providing additional fluidic and photoprotective properties. Because of their optical and surface characteristics, the arrays exhibit a SERS analytical enhancing factor of 500, without any noble metals such as gold or silver. Micro-Raman maps allowed studying LISi properties, identifying maximum amplification in nanostructured areas characterized by the presence of 7 nm Si nanocrystals. These structures are confined by a SiOx layer as illustrated by XPS valence band measurements. The highly hydrophilic LISi areas allow a pre-concentration of target molecules prior to SERS analysis. A relevant application of LISi was found in the detection of apomorphine (APO), a drug used for the treatment of Parkinson's disease. In contrast with what is obtained by using gold SERS substrates, LISi allows the detection of APO with no sign of oxidation. This invites for the use of the Si/SiOx SERS detection in future systems for the personalized delivery of APO.

LanguageEnglish
Pages174-180
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
Volume174
DOIs
Publication statusPublished - Feb 1 2019

Fingerprint

Raman Spectrum Analysis
Biomolecules
Silicon
Raman scattering
Lasers
Raman spectra
Apomorphine
Oxidation
oxidation
silicon
lasers
Gold
Parkinson disease
gold
Silver
Nanoparticles
Parkinson Disease
fluidics
Fluidics
Metals

Keywords

  • Apomorphine
  • Laser modification
  • Parkinson's disease
  • SERS active silicon

ASJC Scopus subject areas

  • Biotechnology
  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

Cite this

Laser writing of nanostructured silicon arrays for the SERS detection of biomolecules with inhibited oxidation. / Pellacani, P.; Torres-Costa, V.; Agulló-Rueda, F.; Vanna, R.; Morasso, C.; Manso Silván, M.

In: Colloids and Surfaces B: Biointerfaces, Vol. 174, 01.02.2019, p. 174-180.

Research output: Contribution to journalArticle

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