Late-appearing Philadelphia chromosome in acute lymphoblastic leukemia

Mario Sessarego, Raffaella Defferrari, Anna Dejana, Emanuele Salvidio

Research output: Contribution to journalArticle


We describe the cytogenetic analysis of a patient affected by a common acute lymphoblastic leukemia, L2 type. At diagnosis and first relapse, the karyotype was normal, whereas at the second relapse more than 60% of the examined cells showed a Philadelphia chromosome, without any change in the morphological and immunophenotypical picture. This case confirms the observation that leukemic cells are susceptible to developing a Ph, considered a primary chromosomal abnormality, during the course of the disease.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

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